Scarcity of labeled data limits development of deep learning biomarkers in oncology. We develop a two-stage AI model predicting pathological complete response (pCR) to neoadjuvant therapy in breast cancer. The first stage learns the transcriptome from histopathology using 8,742 patients across 32 cancer types, corroborated by pathologist review and spatial agreement with measured expression. This simplifies the second stage to predicting pCR from inferred expression and clinical variables. Developed using 1,080 patients (five cohorts) and evaluated in 1,412 patients (nine cohorts), the model achieves a pooled AUROC of 0.79 (95% CI, 0.73-0.85), discriminating responders within molecular subtypes. It outperforms histopathological biomarkers, remaining stable across intratumoral sampling and with minimal biopsy tissue. Ablations show transcriptome-wide inference improves discrimination over clinical variables alone or one-stage pathology models, and robustness by avoiding genomic assays'gene selection constraints. These results indicate that biologically informed compression may generalize to data-sparse applications in precision oncology.
GAOKAO-Bench is introduced, an intuitive benchmark that employs questions from the Chinese GAOKAO examination as test samples, including both subjective and objective questions that contribute a robust evaluation benchmark for future large language models and offers valuable insights into the advantages and limitations...
Xiaotian Zhang, Chun-yan Li, Yi Zong et al.· arXiv.org· 216 citations· ⚡17
This work investigates the possibilities of using LLMs in a resume screening setting via a document retrieval framework that simulates job candidate selection and finds that the MTEs are biased, significantly favoring White-associated names in 85% of cases and female-associated names in only 11.1% of cases.
This paper presents a comprehensive overview of the Ultralytics YOLO family, emphasizing architectural evolution, benchmarking, deployment, and emerging directions from YOLOv5 through YOLO27, and examines detection, segmentation, depth, classification, pose, oriented detection, tracking, export, quantization, and deplo...
A novel threat is unveiled in which attackers steer the RAG system's response by injecting malicious passages into its knowledge base, enabling the attacker to steer the response without altering the user input or modifying the RAG weights.
Jiaqi Xue, Meng Zheng, Yebowen Hu et al.· arXiv.org· 109 citations· ⚡8
This work revisits schema linking when using the latest generation of large language models (LLMs) and finds empirically that newer models are adept at utilizing relevant schema elements during generation even in the presence of large numbers of irrelevant ones.
Karime Maamari, Fadhil Abubaker, Daniel Jaroslawicz et al.· arXiv.org· 109 citations· ⚡19
Empirically, PRISM reduces the end-to-end time for data selection and model tuning to just 30% of conventional pipelines, and achieves this efficiency while simultaneously enhancing performance, surpassing models fine-tuned on the full dataset across eight multimodal and three language understanding benchmarks.
Jinhe Bi, Yifan Wang, Danqi Yan et al.· arXiv.org· 73 citations· ⚡4
With $2.1 million funding from Google.org, the open-source Public Transit Intelligence Hub will unify public transit monitoring, operations, and passenger communication.
Professor Sherry Turkle’s new book, “Artificial Intimacy,” offers a withering critique of chatbots and the antisocial dynamics she believes they encourage.
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