Sep 2026· Molecular and Cellular Biochemistry· Vol 481, pp. 5545-5561· 0 citations· 28 references
Medicine
TL;DR
Functional enrichment analysis revealed that epithelial-mesenchymal transition plays a critical role in CRC tumorigenesis and metastasis, and established a novel three-gene prognostic signature that effectively predicts clinical outcomes in CRC patients.
Keratin19 (KRT19) is the smallest type I KRT protein which is a member of the keratin family. KRT19 has been reported as a diagnostic marker in several cancers, such as lung, breast and pancreatic cancer. However, the diagnostic value and potential role of KRT19 in colorectal cancer (CRC) remain to be explored. Our stu...
Qi-Ran Zhu, Ying Cui, Cheng Cheng et al.· General Physiology and Bioph...· 0 citations
Silencing of TMEM33 markedly suppresses CRC cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) both in vitro and in vivo, and significantly reduces subcutaneous tumor growth and pulmonary metastatic burden.
Rui Li, Li Zhao, Nan-Nan Chai et al.· Human Cell· 0 citations
Colorectal cancer (CRC) is a leading cause of cancer-related mortality
worldwide, largely attributable to limitations in early detection and patient stratification. Although
N6-methyladenosine (m6A) modification has emerged as a critical epitranscriptomic regulator in
cancer biology, its role in driving molecular h...
Yan Cao, Shan He, Xue Xue et al.· Current Bioinformatics· 0 citations
Colorectal cancer (CRC) is a leading cause of cancer-related deaths, with disease progression and distant metastasis being the major determinants of mortality. The ion channel transient receptor potential melastatin-4 (TRPM4) has been associated with several types of cancer and has been shown to regulate key cellular f...
Irida Papapostolou, Sofia Jarrin, B. Hauert et al.· Cell Calcium· 0 citations
Colorectal cancer (CRC) ranks among the most prevalent malignancies globally, yet exhibits limited responsiveness to immunotherapy. This therapeutic challenge stems primarily from incomplete understanding of immune microenvironment regulation in CRC. Although Eomesodermin (EOMES) has been implicated in tumor immune che...
OBJECTIVE
To investigate FUBP1 expression, its prognostic value, impact on the tumor microenvironment (TME), and drug sensitivity in colorectal cancer (CRC), and to explore its potential underlying mechanisms.
METHODS
Using data from The Cancer Genome Atlas (TCGA), we analyzed FUBP1 expression in CRC, evaluated its p...
Zhen-Xiang Li, Yan-Fang Zhao, Yan-Li Si et al.· Cancer Treatment and Researc...· 0 citations
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