It is suggested that ERK signaling is associated with early follicular development in zebrafish, and exposure to the ERK inhibitor was associated with reduced ERK phosphorylation and fewer advanced follicles.
Abstract
Simple Summary Early ovarian development depends on the progression of primary follicles (PFs) through distinct developmental stages. However, the signaling pathways involved in these transitions remain unclear in fish. We reanalyzed previously published transcriptomic and DNA methylation datasets from four PF subtypes in zebrafish and conducted additional experiments to examine ovarian development following exposure to the ERK inhibitor SCH772984. Inhibitor exposure was associated with reduced ERK phosphorylation and fewer advanced follicles. These findings suggest that ERK signaling is associated with early follicular development in zebrafish.
Embryonic ovarian development requires high levels of WNT/ß-catenin signaling yet the molecular basis of this requirement remains unclear. Mutations in the WNT potentiator RSPO1 impair ovarian development in both mouse and human, leading to gonadal masculinization in XX individuals. Here, we show that RSPO1 acts within...
F. Tang, Natividad Bellido-Carreras, Kheira Bouzid et al.· bioRxiv· 0 citations
Embryonic diapause is a reversible dormant state that allows mammalian blastocysts to survive periods of environmental or metabolic stress. In this issue of Developmental Cell, Furlan et al.1 report that Nodal/Smad2 signaling sustains diapause by repressing Pparg-driven lipid storage in the blastocyst.
Oocyte activation and follicular development are fundamental for fertility in mammals, yet the dynamics of activated oocytes (Act-Oos) remain unclear. Here we use a Zp3-based lineage-tracing mouse model to label Act-Oos and reconstruct their developmental trajectories and folliculogenesis across the lifespan. We uncove...
Jing Liang, Xue-Bing Yang, Qian Li et al.· Nature Aging· 0 citations
This study analyzed transcriptomic differences between SYF and F6 follicles in Zi geese. A total of 4,505 DEGs were identified, indicating strong transcriptional reprogramming during follicle selection. Enriched pathways were related mainly to ECM-receptor interaction, focal adhesion, and neuroactive ligand-receptor si...
In conclusion, pharmacological activation of the mTOR pathway did not positively influence TE differentiation in bovine embryos; however, it effectively rescued the unexpected negative effects induced by the vehicle on TE cell number and YAP1 signaling.
M. Vilioti, Beatriz Cartaxo Ragnelli, F. Berling et al.· Reproductive Biology· 0 citations
Early postnatal heart growth requires a transition from cardiomyocyte proliferation to enlargement and binucleation. Using morphometric, transcriptomic, signaling, and single-cell analyses in neonatal mice, we show that this transition occurs predominantly between postnatal day 3.5 and 4.5 (P3.5-P4.5), accompanied by d...
Hui An, Hao Hu, Sai-Jing Chen et al.· Development· 0 citations
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