Design, synthesis, and anti-prostate cancer activity evaluation of novel thieno[2,3-b]pyridine derivatives as potential BLM helicase inhibitors.

Wei Tu Ningning Zan Xinyu Liu Gang Yu Xiaoping Zeng Yafang Zhou Jia Yu Xue Meng Kun Liu Xiaolin Peng Sha Cheng Bi-Xue Xu Guangcan Xu

Jul 2026 · Molecular diversity · 0 citations · 55 references

Medicine

TL;DR

Nine novel thieno[2,3-b]pyridine derivatives were rationally designed and synthesized based on a versatile key intermediate, representing a promising lead compound for the development of novel BLM-targeted anti-prostate cancer agents.

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