ORIGINAL INVESTIGATION

Is Stress Reactivity an Intermediary Mechanism in the Association Between NR3C1 Methylation and Adolescent Loneliness?

This study examined whether saliva-derived DNA methylation in the glucocorticoid receptor (NR3C1) gene was linked to loneliness through dysregulation of the hypothalamic-pituitary-adrenal axis (HPA-axis) in 101 early adolescents (Mage = 11.61 years, SDage = 0.64, 55.45% girls). Using person-centered analyses to account...

CLOCK rs1801260 and MTNR1B rs10830963 Polymorphisms Modulate the Association between Cholesterol Levels and Circadian Rhythms in Arctic Residents

Genetic evidence for a causal relationship between melatonin metabolism and depression.

To investigate the causal relevance of melatonin metabolism, which provides the biological basis for circulating melatonin levels, to specific depression symptom subtypes, we performed a targeted systematic review of melatonin metabolism pathways in the human brain and liver. Using two-sample Mendelian randomization (M...

Anxiety and Depression Traits Are Moderated by a Sex-Dependent Genetic Interaction Between 5-HTTLPR and BDNF

The findings reveal a complex, sex-dependent genetic interaction that selectively influences anhedonia and anxiety, which highlights the value of considering sex-stratified genetic backgrounds and symptom specificity to advance personalised precision medicine in psychiatry.

CLOCK 3111T/C Polymorphism and Sex Moderate the Effect of Childhood Trauma on White Matter Microstructure in Bipolar Disorder

Background. Bipolar disorder (BD) is characterized by circadian rhythm disruptions, contributing to mood instability and recurrence. These rhythms are regulated by clock genes in the suprachiasmatic nucleus, including the CLOCK 3111T/C (rs1801260) polymorphism that has been linked to delayed sleep phase, insomnia, and...

Association between physical activity level and gut microbiota profiles in individuals with subthreshold depression: a cross-sectional study

Although PA level was not significantly associated with overall gut microbial diversity in college students with SD, it was closely associated with the differential distribution of specific functional genera, closely associated with the differential distribution of specific functional genera.