TL;DR
Overall, this study identifies the HSV-1 ICP0 E3 ubiquitin ligase as a key determinant of the fate of CIN85 endosomes, which are important for immunoevasion.
Hepatitis E virus (HEV) is a major cause of acute viral hepatitis, with an estimated 20 million human infections annually. Its diverse host range presents a significant zoonotic threat, yet the molecular mechanisms underpinning HEV–host interactions remain poorly characterised. Here, we used transposon-based insertion...
Recombinant viruses containing either glycoprotein B (gB) or glycoprotein K (gK) mutations that confer a syncytial phenotype, and with or without UL45 expression, were generated to revisit the role of 18K in mediating cell fusion and showed that UL45 expression was not required for either gB- or gK-driven syncytial pla...
Enteroviruses are among the most common viral pathogens in humans, causing illnesses ranging from the common cold to severe and sometimes life-threatening diseases such as acute haemorrhagic conjunctivitis or poliomyelitis. To replicate efficiently within host cells, enteroviruses hijack several host factors, including...
Infectious bursal disease virus (IBDV) and infectious pancreatic necrosis virus (IPNV) are major animal pathogens that impose a heavy burden on the poultry and aquaculture industries. Yet, major aspects of their unique replication program remain unknown. IBDV is unusual among double-stranded RNA viruses in that it repl...
Although reticulophagy, the selective autophagy of the endoplasmic reticulum (ER), restricts several RNA viruses, whether this pathway constrains DNA virus infection remains unknown. Recently, we found that FAM134B (family with sequence similarity 134 member B), an ER-resident cargo receptor that mediates reticulophagy...
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