TL;DR
Spatial transcriptomics morphologically and transcriptionally characterizes the polycystic kidney disease transcriptome and may provide clinically-relevant disease associations that inform mechanistic studies in animal and organoid models.
Current transcriptomic evidence distinguishes molecular profiles across phenotypes such as minimal change disease, focal segmental glomerulosclerosis, and steroid-sensitive versus steroid-resistant disease in Pediatric nephrotic syndrome.
Background and Objectives: LHFPL5 encodes a four-pass transmembrane protein essential for cochlear mechanotransduction, but its molecular behavior in cancer remains poorly defined. We characterized the genomic, epigenetic, transcriptomic, immune, and cellular context of LHFPL5 in clear cell renal cell carcinoma (KIRC)...
Spatial transcriptomics is increasingly used to infer cellular phenotypes, molecular interactions, and functional tissue organization from RNA, although most of these biological processes are ultimately mediated by proteins. Here, we directly tested the interchangeability of spatial RNA and protein measurements using p...
Allele-specific expression (ASE), the preferential expression of one gene copy, is a key mechanism of genomic regulation. However, its role in human kidney disease remains poorly understood. In this study, we generated a high-quality, genome-wide ASE map using paired whole-genome sequencing and RNA sequencing from micr...
INTRODUCTION Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the slow, progressive formation of fluid-filled cysts within the kidneys, ultimately leading to kidney failure. Despite being the most common genetic kidney disease, therapies for ADPKD are limited. Ureteric bud (UB) organoids derived...
Diabetic nephropathy (DN) arises through complex pathological mechanisms that remain incompletely understood. This study employs transcriptomic and single-cell RNA sequencing (scRNA-seq) approaches to systematically characterize gene expression patterns, cellular composition changes, and intercellular communication net...
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