A dual-aptamer-based, dual-mode FRET lateral flow strip is developed for the rapid and sensitive detection of thrombin in serum samples, achieving a fluorescence-based detection limit of 0.135 nM-twice as sensitive as the colorimetric method.
A dual-mode colorimetric–photothermal LFIA platform was successfully constructed for the detection of thrombosis-related biomarkers, including thrombomodulin and α2-plasmin inhibitor–plasmin complex, in clinical serum samples, enhancing analytical sensitivity and reliability.
Jun Yin, Yu Qiu, Yao Nie et al.· RSC Advances· 0 citations
A preliminary evaluation using serum samples from five breast cancer patients and five healthy individuals showed clearly distinguishable colorimetric and fluorescent responses between the two groups, supporting the effectiveness of the proposed probe for miRNA-21 detection in real serum samples and indicating the potential of the dual-signal LFA platform for further clinical application.
Ruien Shi, Qian Xiang, Yajuan Chang et al.· Talanta: The International J...· 0 citations
A luminescence resonance energy transfer (LRET)-regulated dual-readout lateral flow immunoassay (LFIA) is reported that integrates naked-eye colorimetric screening and near-infrared-excited quantitative luminescence analysis on a single test strip, offering a versatile platform for rapid on-site screening of small-molecule contaminants in complex matrices.
Yechen Cheng, Chaofan Zhang, Xinfeng Dai et al.· Microchimica Acta· 0 citations
This programmable dual-aptamer amplified luminescent proximity homogeneous assay (AlphaLISA) provides a rapid, homogeneous, and highly adaptable strategy for tumor-derived sEVs analysis, offering promising potential for noninvasive cancer diagnostics.
A novel, enzyme-free surface-enhanced Raman scattering (SERS) platform based on a "dual-hotspot amplification" strategy that enhances detection sensitivity but also provides a useful design concept for the ultrasensitive analysis of carbohydrate-derived biomarkers.
Meiqi Bao, Xiaoyan Ma, Hongcai Liu et al.· Biosensors & bioelectronics· 0 citations
A dual-mode aptasensor based on magnetic separation with a sequential signal conversion mechanism is developed for sensitive and specific detection of HepG2 cells, exhibiting high specificity for HepG2 over other tumor cells.
Yiwen Zheng, Liquan Zhu, Kang Yao et al.· Microchimica Acta· 0 citations
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