Identifying Modifiable Factors and Their Joint Effect on Amyotrophic Lateral Sclerosis: A Prospective Cohort Study in the UK Biobank

Abstract

Hypothesis‐driven studies have linked numerous risk factors to amyotrophic lateral sclerosis (ALS). However, the full extent of their diversity and co‐occurrence has not been adequately appreciated. This study aims to comprehensively explore the modifiable risk factors for ALS and to evaluate the potential benefit of controlling these factors.