Sep 2026· World Journal of Microbiology & Biotechnology· Vol 42· 0 citations· 32 references
Medicine
TL;DR
Significant differences in signal class and report burden contributed graded contextual evidence, but organism-level attribution required clinical review and orthogonal microbiology rather than binary positivity alone.
Background Bloodstream infections (BSIs) are a major cause of sepsis and mortality in critically ill patients, yet accurate pathogen identification remains challenging because blood culture has limited sensitivity and delayed turnaround time. This study aimed to evaluate the complementary diagnostic value of blood cult...
Yu-Chong Chen, Xiao Zou, Ying Zhong et al.· Infection and Drug Resistanc...· 0 citations
Polymicrobial bloodstream infections (BSIs) are clinically challenging because conventional blood culture may fail to recover all causative microorganisms, particularly in patients with low microbial burden, prior antimicrobial exposure, or infections caused by fastidious organisms. This study evaluated a 16S rDNA...
Guang-Qi Li, Geng Wu, He Yin et al.· Frontiers in Microbiology· 0 citations
To evaluate the diagnostic performance of plasma metagenomic next‑generation sequencing (mNGS) for suspected bloodstream infections (BSI) and localized infections in patients with advanced HIV disease.
We conducted a retrospective observational study of 110 patients with advanced HIV disease who underwent...
Bo He, Man Chen, Yong-Fang Jiang et al.· BMC Microbiology· 0 citations
AIM
Lower respiratory tract infections frequently involve polymicrobial disease and antimicrobial-resistant pathogens, yet conventional culture may provide an incomplete and delayed microbiological picture. This study evaluated the complementary contribution of multiplex molecular testing and conventional culture in a...
Y. Elmahdy, Atef S. Elgebaly, Menna Al-Adl et al.· Journal of Applied Microbiol...· 0 citations
Microbial cell-free DNA (mcfDNA) metagenomic next-generation sequencing (mNGS) is a promising technique for diagnosing infectious diseases. However, research on mcfDNA-based mNGS for diagnosing infections in liver transplantation (LT) recipients remains limited. The aim of this study was to evaluate the diagnostic...
Yongseop Lee, Eunki Min, Yu Jin Park et al.· Frontiers in Cellular and In...· 0 citations
Background/Objectives: Untargeted metagenomic sequencing of microbial cell-free DNA or RNA in plasma or serum offers pathogen detection without lumbar puncture or biopsy, but its value in suspected central nervous system (CNS) infection is uncertain. We reviewed diagnostic yield, agreement with CNS-site testing, clinic...
F. Bratosin, H. Branea, Elena Hogea· Diagnostics· 0 citations
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