Formulation and Characterization of Rimegepant-Loaded Polymeric Nanoparticles for Enhanced Solubility and Oral Delivery

Abstract

The present study was aimed at the formulation and characterizationof Rimegepant (RMG)-loaded polymeric nanoparticles (NP) for enhancedsolubility and oral delivery. RMG-loaded NP were prepared by thenanoprecipitation method using Eudragit RL100 as polymer and PVA asstabilizer. Preformulation studies confirmed the limited aqueous solubility ofRMG and compatibility with selected excipients. The λmax of RMG was foundto be 264 nm, and the calibration curve showed good linearity in the range of 2–12 μg/mL. Six formulations were prepared by varying polymer concentration.Among them, F3 showed optimum performance with satisfactory drug content,entrapment efficiency, redispersibility and in vitro drug release. F3 released85.42% drug within 20 minutes compared with 50.72% release from pure drug.Release kinetics indicated first-order release with anomalous diffusion. Stabilitystudies showed no significant changes during storage. Thus, polymeric NPimproved the dissolution behaviour of RMG.