Evaluating the Effect of Bone Morphogenetic Protein on Dental Implant Stability and Marginal Bone Level Following Immediate Implant Placement (Randomized Controlled Clinical Study).
Aug 2026· The Journal of craniofacial surgery (Print)· 0 citations· 40 references
Medicine
TL;DR
The addition of rhBMP-2 to a biphasic calcium phosphate graft did not confer significant clinical advantages over the graft alone following immediate dental implant placement, suggesting limited additional benefit relative to its cost.
Abstract
Background
Immediate implant placement has become a widely accepted treatment modality because of reduced treatment time and preservation of alveolar bone architecture. Recombinant human bone morphogenetic protein-2 (rhBMP-2) has been proposed to enhance peri-implant bone regeneration and implant stability. This study evaluated the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) combined with biphasic calcium phosphate graft on implant stability and peri-implant bone preservation following immediate implant placement.
Methods
Twenty-four patients who received 32 immediate dental implants were randomly assigned to 2 groups. The control group received a biphasic calcium phosphate graft alone in the jumping gap, whereas the study group received the graft combined with 0.1 mg rhBMP-2. Implant stability, marginal bone level, and buccal bone thickness were evaluated clinically and radiographically over 16 weeks.
Results
Thirty implants were analyzed. Both groups showed a significant increase in implant stability over 16 weeks. The control group demonstrated a slightly higher relative percentage increase than the study group (11.17%±4.34 versus 9.57%±3.83), with no statistically significant difference between groups (P=0.637). No statistically significant differences were observed regarding marginal bone loss or buccal bone thickness changes at 1 mm and 2 mm below the implant screw (P>0.05).
Conclusions
The addition of rhBMP-2 to a biphasic calcium phosphate graft did not confer significant clinical advantages over the graft alone following immediate dental implant placement, suggesting limited additional benefit relative to its cost.
Neither the choice of drilling technique nor the implant macrogeometry significantly influences insertion torque or stability levels in regions of low bone density in this randomized controlled clinical study.
Worood A Akram, S. Bede· The Journal of craniofacial...· 0 citations
Immediate implant placement remains challenged by marginal bone loss and peri-implant soft tissue instability despite its clinical advantages. Therefore, it is of interest to evaluate the effectiveness of i-PRF–enhanced bone grafts combined with amniotic membrane in 100 patients undergoing immediate implant placement and zirconia crown rehabilitation. Patients receiving i-PRF, bone graft and amniotic membrane showed significantly better plaque index, gingival index, probing depth, implant stability and marginal bone preservation than those receiving bone grafts alone (p < 0.05). The adjunctive use of i-PRF and amniotic membrane improved both clinical and radiographic outcomes during the 6-month follow-up period. Thus, combining i-PRF with amniotic membrane may enhance peri-implant tissue regeneration and implant stability, improving the predictability of immediate implant therapy.
Introduction: This study aimed to compare implant stability and crestal bone loss between titanium platelet-rich fibrin (T-PRF)-treated implants and conventional implants. Methods: A prospective, randomized, split-mouth clinical trial was conducted in 10 healthy patients, with 20 implants per mouth (test and control). Each patient received one T-PRF-treated implant and one conventional implant. Implant stability was assessed using implant stability quotient (ISQ) at placement and at 3 months. Crestal bone loss was evaluated radiographically at 3 and 6 months. Soft tissue parameters were assessed at follow-up visits. Results: The T-PRF group showed higher ISQ values and reduced bone loss, with trends favoring the intervention at the three-month follow-up compared with the control group. Bone loss at three and six months was lower around anterior implants in the T-PRF group than in the control group. At this time, T-PRF may help improve soft tissue measurements; however, the measured values did not differ significantly from those of the control groups. Due to limitations such as a small sample size, a relatively short follow-up period, and varying baseline crestal bone levels, these findings should be interpreted with caution. Conclusion: Due to the restrictions of this split-mouth study, T-PRF-treated sites showed a trend towards increased early implant stability and decreased crestal bone loss compared to control sites. However, because of the small sample size and short follow-up period, conclusive evidence cannot be drawn about the clinical superiority of T-PRF. Further appropriately powered randomized controlled trials with prolonged follow-up periods are necessary to determine the long-term clinical efficacy of T-PRF in implant therapy. Clinical Trial Registration number: CTRI/2022/11/047159.
Anuraga Tejaswi Thotimpuri, M. Pasupuleti, G. Penmetsa et al.· Journal of Advanced Periodon...· 0 citations
Within the limitations of this study, implants with a nanoscale super-hydrophilic surface did not result in significantly greater bone regeneration than conventional moderately rough implants following transcrestal sinus floor elevation, although a trend toward increased bone volume was observed.
L. Canullo, D. Baldi, P. Pesce et al.· Oral and Maxillofacial Surge...· 0 citations
Background and Objectives: Immediate dental implants placed at the time of extraction help preserve alveolar bone, maintain soft tissue architecture, and reduce treatment time. However, compromised bone and soft tissue deficiencies may affect implant outcomes, requiring regenerative approaches. Silk fibroin derived from Bombyx mori has gained attention as a biomaterial because of its favourable mechanical properties and biocompatibility. This study aimed to compare cross-linked bovine collagen membranes with and without silk fibroin around immediate dental implants for soft tissue regeneration.
Materials and methods: Twenty healthy individuals were randomised into two groups following non-surgical periodontal therapy. Group I (Control) received a Cross-linked collagen membrane following immediate implant placement (n = 10), while Group II (Test) received a cross-linked collagen membrane with silk fibroin (n = 10). Immediate implant healing was assessed at the end of the 10th day, 1 month, and 3 Months postoperatively. Gingival tissue thickness (GTT) and keratinised tissue width (KTW) were evaluated at 1 month and 3Months. Bone assessment was performed at baseline and at 3 months post-intervention using Radiovisiography.
Results: Silk fibroin membrane demonstrated significant gingival tissue thickness and enhanced keratinised tissue width with improved wound healing, and greater peri-implant bone stability compared to collagen membrane alone.
Conclusion: Collagen membranes incorporated with silk fibroin may enhance soft tissue regeneration and peri-implant bone stability around immediate implant sites.
Clinical Relevance: Functional composite membrane (Silk fibroin +Collagen) for Soft and Hard tissue augmentation around immediate implants provides greater peri-implant stability.
Jyoti T Naik, Rudrakshi C, M. Prabhuji· Journal of Biology and Medic...· 0 citations
The Bone Ring Technique (BRT) is a newer viable option for restoring complex defects around dental implants with three-dimensional bone augmentation with significant height and width augmentation of buccal bone.
Priyadharshini Annamalai Senthur Pandian, Aniz Amanullah, Lakshmiganthan Mahalingam et al.· Journal of Clinical and Diag...· 0 citations
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