This hypothesis-driven narrative review integrates adaptive gain theory, locus coeruleus–norepinephrine (LC–NE) anatomy and pathology, LC-sensitive MRI, pupillometry, EEG/fMRI state dynamics, sleep research, behavioral variability, and Alzheimer's disease biomarkers to examine how disease-related vulnerability becomes...
Seyed Kiarash Sadat Rafiei, Mahsa Faramin Lashkarian, Seyede Helma Naseri Sadr et al.· Journal of Alzheimer's Disea...· 0 citations
Alzheimer's disease (AD) is characterized by progressive cognitive decline associated with synaptic and large-scale network dysfunction. Resting-state alterations may provide functional correlates of AD pathology, but associations among intrinsic brain activity, biomarkers, and domain-specific cognition have not been s...
Soraya Alfonsín, Brenda Chino, J. de Frutos-Lucas et al.· NeuroImage: Clinical· 0 citations
Findings support the utility of plasma p-tau217 as a biomarker in this population and underscore the role of sleep processes in the relationship between neurodegenerative pathology and cognition in older adults with epilepsy.
R. Sarkis, Hyun-Sik Yang, Lei Liu et al.· Neurology· 0 citations
A practical multi-axis framework comprising clinical phenotype, AD biological context (AD pathology plus co-pathologies and molecular modifiers), network topography (regional patterns) and tempo (rate of clinical and biomarker progression) is proposed to reduce diagnostic mismatches, make cohorts more comparable and su...
L. Grinberg, M. Murray· Nature Reviews Neurology· 0 citations
This study mapped whole-brain connectivity of the locus coeruleus (LC) across aging and the Alzheimer’s disease (AD) continuum and introduced a novel imaging marker called the LC gap, which quantifies deviations in LC connectivity patterns. Among several LC gap measures, left-right asymmetry was the most informative: i...
Blanca Zufiria, D. Veréb, M. Mijalkov et al.· Emerging Topics in Artificia...· 0 citations
Neuroinflammation is implicated in Alzheimer’s disease (AD) pathogenesis, yet how changes in TSPO PET signal are associated with tau deposition, and how brain network architecture shapes this relationship remain poorly understood. We conducted a prospective, multimodal neuroimaging study in 56 participants: 35 amyloid-...
M. Öchsner, M. Brendel, N. Franzmeier et al.· Alzheimer's Research & Thera...· 0 citations
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