TL;DR
The present review aims to summarize the molecular mechanisms behind the neuroprotective activity and potential application of various antidiabetics in neurodegenerative diseases, namely metformin, liraglutide, pioglitazone, linagliptin, dapagliflozin, glibenclamide, exenatide, and imeglimin.
An in-depth review of medicinal plants with anti-neuroinflammatory properties, focusing on their bioactive compounds, mode of action, and clinical applications in neurological disorders is given.
Alzheimer's disease (AD) is a progressive and multifactorial neurodegenerative disorder involving metabolic dysfunction, neuroinflammation, mitochondrial impairment, synaptic failure, and neuronal loss. Although amyloid-beta deposition and neurofibrillary tangles composed of hyperphosphorylated tau remain central patho...
INTRODUCTION Afflicting 50 million people worldwide, epilepsy accounts for a sizeable burden among neurological diseases. Its progression, termed epileptogenesis, and the sole availability of medications with negligible effects against its clinical course in the market render epilepsy largely incurable. As studies illu...
Chronic neuroinflammation mediated by activated microglia constitutes a central pathogenic mechanism underlying neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS). Despite substantial progress in elucidating disease mechanisms, effective disease-modifyi...
This review discusses multi-target neuroprotective mechanisms of curcumin, critically reviews the preclinical success and human clinical trial outcomes, and highlights advanced nano formulations (solid lipid nanoparticles, colloidal sub-micron dispersions, polymeric nanoparticles, multi-walled carbon nanotubes and exos...
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