In Vitro Development and Characterization of a Chitosan/PVA/Starch Hydrogel Film Incorporating Zinc Oxide Nanoparticles and Syzygium cumini Extract: Physicochemical, Antimicrobial, and Cytocompatibility Evaluation
Preliminary in vitro evidence is provided for S3 as a candidate hydrogel for infection-resistant wound-contact applications and claims relating to implant-associated infection management require dedicated in vivo biofilm and implant-model validation studies not yet performed here.
A hydrogel of chitosan, hydroxypropyl methylcellulose, and propylene glycol, incorporating lyophilized hAM particles to combine the hydrogel's physicochemical properties with hAM's bioactivity shows promising properties for wound dressings.
Zahra Chegeninezhad, M. Setayeshmehr, M. Zeinalian et al.· Biochemical and Biophysical...· 0 citations
Chronic wounds infected by Candida albicans impose a significant clinical burden, yet topical amphotericin B (AMB) delivery is constrained by low aqueous solubility. Wet-spun poly(vinyl alcohol) (PVA)/chitosan fibres loaded with an AMB/hydroxypropyl-γ-cyclodextrin (HP-γ-CD) inclusion complex were developed as a sustained-release antifungal wound dressing. Phase solubility analysis confirmed inclusion complex formation with an apparent stability constant of 36.1 × 103 M⁻1 in distilled water (AL-type profile, R2 = 0.9984), characterised by Fourier-transform infrared spectroscopy (FTIR), 1H NMR, and scanning electron microscopy (SEM). IC-SE-1 achieved ∼ 354-fold and ∼ 136-fold solubility enhancement in distilled water and phosphate-buffered saline (PBS, pH 7.4), respectively, while fully retaining antifungal activity (MIC = 1 µg/mL; p = 0.112 vs. pure AMB). The complex was incorporated into fibres at four PVA:chitosan ratios and crosslinked with tripolyphosphate and glutaraldehyde. Formulation P6C4 (PVA 60%:chitosan 40%) demonstrated the most favourable overall performance, with the highest water-holding capacity (346.51 ± 4.10%), swelling (463.40 ± 11.12%), tensile strength (18.47 ± 2.18 MPa), and elongation (431.57 ± 52.22%). Woven fibres maintained inhibition zones against C. albicans from day 2 to day 7, with AMB release exceeding the MIC throughout, while haemolysis remained below 5% (ASTM F756-08). HP-γ-CD complexation enables sustained above-MIC AMB delivery from a dual-crosslinked biopolymeric dressing, providing in vitro proof-of-concept for Candida-infected chronic wounds, pending cytotoxicity and in vivo validation.
Unknown authors· International journal of pha...· 0 citations
Overall, ZnONPs improved antibacterial activity, HAp provided the most favorable cytocompatibility and stability profile, while GONs showed a comparatively higher hemolytic response, highlighting the importance of nanoparticle selection in designing PVA/SA hydrogel scaffolds for tissue-contact applications.
N. Abuhamed, E. Dinçer, K. Öksüz· ACS Omega· 0 citations
A novel multifunctional wound dressing by integrating Petroselinum crispum (parsley, PS) extract and zinc ascorbate-based metal-organic frameworks (MOFs) into a polyvinyl alcohol (PVA) nanofibrous matrix that combines biodegradability, biocompatibility, and enhanced bioactivity for wound healing is reported.
Shimaa Husien, Rana R. Haikal, Eman A. Khalil et al.· Journal of Biological Engine...· 0 citations
The developed wafer showed strong potential as an antibacterial wound dressing, providing controlled drug release along with fast-acting relief from bacterial infections and the anti-microbial potential of wafers was confirmed using the disc diffusion method.
S. Chowdhury, Syed Mahmood, M. A. Mirza et al.· Scientific Reports· 1 citation
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
