TL;DR
Findings indicate that PLGA-MIN/CUR coatings represent a promising multifunctional strategy for enhancing implant surface performance and preventing or managing peri-implantitis.
Background Bacterial infection and insufficient osseointegration of titanium-based implants remain major clinical challenges. Conventional drug-loaded coatings often fail to simultaneously achieve long-term antibacterial activity and the construction of an osteogenic microenvironment. Methods In this study, a graphene oxide-supported silver nanoparticle/silk fibroin (GO@Ag/SF) composite coating was developed and modified via micro-arc oxidation. By precisely controlling the GO/AgNO3 volume ratio, the antibacterial and osteogenic performances of the coatings were systematically evaluated. A rat model of infectious bone defect was employed to verify the in vivo therapeutic efficacy. Results The optimized GO@Ag-2/SF coating exhibited pH-responsive sustained Ag+ release, with cumulative release increasing from 0.23 μg/mL under physiological conditions to 0.69 μg/mL under acidic conditions over 672 h. Under NIR irradiation, the coating reached 59.8°C within 10 min and achieved potent antibacterial activity against S. aureus and E. coli, with inhibition rates up to 98.3 ± 1.2%. The GO@Ag-2/SF coating also promoted osteogenic differentiation by enhancing ALP activity, collagen secretion, calcium mineralization, and the expression of RUNX-2, ALP, COL-I, and OCN. In vivo, GO@Ag-2/SF reduced inflammatory infiltration and improved peri-implant bone regeneration, with increased BIC, BV/TV, and Tb.Th and reduced Tb.Sp. Moreover, pull-out testing demonstrated the highest bone-implant mechanical fixation in the GO@Ag-2/SF group, confirming enhanced functional osseointegration in the infected bone defect model. Conclusion Through the synergistic effects of its components, the GO@Ag/SF coating established a dynamic antibacterial-osteogenic balance, offering a promising strategy for the repair of infectious bone defects.
The CurcloDent coatings demonstrated effective antibacterial activity against Staphylococcus aureus, Enterococcus faecalis and Pseudomonas aeruginosa through surface-mediated antimicrobial action, and therefore may help to increase the lifespan of the implant.
Findings suggest that the synthesized hydrogel (BSG‐CHI) provides a favorable microenvironment for tissue regeneration and wound management applications.
The multifunctional coating provides sustained antimicrobial activity alongside immunomodulatory and pro-regenerative effects, supporting its potential to treat implant-related infections while enhancing peri-implant soft tissue remodeling.
Periodontitis is a chronic oral inflammatory disease commonly caused by bacterial infection that affects oral health. Ciprofloxacin (CIP) is an antimicrobial agent with low water solubility (0.067 mg/mL at 25 °C, pH 7.5) and poor permeability. This research aims at fabricating chitosan/gellan gum hybrid extended release in-situ forming implants (CG-IFIs) loaded with CIP/Poloxamer 407 solid dispersion for treatment of periodontitis. Solid dispersions were loaded into chitosan/gellan gum matrix, cross linked with 2% w/v sodium bicarbonate. Upon exposing the implants to body temperature, a sol-gel transition occurs. The implants were evaluated for gelation time, injectability, in-vitro drug release, surface morphology and erosion rate. Results indicated that formulation (CG-IFI3) comprising 1% (w/v) chitosan, 0.2% (w/v) gellan gum, and a 2:1 w/w ratio of Poloxamer 407/CIP solid dispersion exhibited an appropriate gelation time (12 ± 2.5 min), favorable flow rate (0.83 ± 0.05 ml/min), and sustained drug release over two weeks. The selected formulation (CG-IFI3) was injected intragingivally into the mandibular incisive region of a rat model after induction of periodontitis via the ligature method. After 15 days of treatment, CG-IFI3 significantly reduced periodontal inflammation, vascular congestion, and tissue infiltration. These findings suggest that CG-IFI3 is a promising localized delivery system for managing periodontitis.
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