AMX-CuONPs bio-nanocomposite film showed rapid biodegradation within 35 days, whereas the maximum zone of inhibition was observed in Antimicrobial Resistance (AMR) and non-AMR bacterial strains.
Abstract
The widespread use of plastic-based medical materials, such as bandages, syringes, and biomedical packaging, has led to serious health problems owing to their inappropriate disposal and non-biodegradability. This study focused on the fabrication and characterization of potato-starch-based films infused with amoxicillin-loaded CuONPs (AMX-CuONPs) for biomedical applications. CuONPs were synthesized using Bacopa monnieri leaf extract, which was functionalized with amoxicillin. The properties of the bio-nanocomposite films were characterized morphologically (SEM and EDX), mechanically (tensile strength and elongation at break), structurally (XRD and FTIR), and for biodegradability and antimicrobial activity. The AMX-CuONPs bio-nanocomposite film (AC-BF) exhibited a thickness of 0.69 mm, density of 1.33 g/cm3, tensile strength of 0.63 MPa, and the highest elongation break of 49%. XRD analysis revealed the amorphous nature of the film, while FTIR analysis revealed the functional groups such as C-H, O-H, C = O, C = C, and Cu-O, indicating AMX-CuONPs integration into the starch-based films. SEM analysis showed homogeneity and particles embedded on the surface of AC-BF. Furthermore, AC-BF showed rapid biodegradation within 35 days, whereas the maximum zone of inhibition was observed in Antimicrobial Resistance (AMR) and non-AMR bacterial strains. These results suggest the potential of these materials for biomedical packaging, wound healing bandages, and patch applications.
This study presents the development of a sustainable antimicrobial nanofibrous system by incorporating biosynthesized CuO NPs (copper oxide nanoparticles) into electrospun polymeric matrices. Aqueous extracts of the brown marine alga Sargassum ilicifolium were utilized for ultrasonic-assisted extraction, enabling an environmentally friendly nanoparticle synthesis process. The resulting CuO NPs exhibited nanoscale dimensions (~108 nm), monoclinic crystallinity, and moderate dispersion stability (−18.3 mV), as confirmed through UV–Vis, FTIR, XRD, SEM, TGA, and DLS analyses. These nanoparticles were homogeneously embedded within starch/PVA solutions and electrospun to produce uniform, bead-free fibers with a porous architecture. Antimicrobial performance was evaluated against pathogenic microorganisms. The nanoscaffolds (50 µg/mL) demonstrated superior inhibitory activity compared to both the algal extract and standalone nanoparticles, with maximum zones observed for E. coli (31±0.16 mm) and Penicillium sp. (27±0.23 mm). The fabricated polymeric nanoscaffolds promoting effective microbial contact and sustained ion release, highlighting their potential as eco-friendly antimicrobial biomaterials.
Rajendraprasad Kunamalla, Mani Panagal, C. Palanisamy· Genetics and Molecular Resea...· 0 citations
Synthetic materials used to enhance the productivity of agricultural crops have, in turn, begun to exert negative impacts on soil ecology. This has led to an increased interest in environmentally safe biomaterials. In this context, an antibacterial biofilm was developed based on oxidized starch and microcrystalline cellulose (MCC) as well as cellulose nanofibers (CNFs) derived from corn husk (CH). According to the obtained results, the film containing 3% CNFs exhibited the highest mechanical strength, reaching 3.87 MPa. To impart antibacterial properties to the resulting biofilm, different volumetric amounts of copper nanoparticles (CuNPs) synthesized via a green method were incorporated. As a result, the biofilm containing 1 mL of CuNPs demonstrated the highest antibacterial activity. It was also found that, compared to the pristine film, the mechanical strength of the CuNPs-immobilized biofilm decreased by threefold, while its flexibility increased. The antibacterial biofilm was comparatively characterized using FTIR, XRD, SEM, and TGA techniques, and its physicochemical properties were determined. The biodegradation behavior of the biofilm in soil was also investigated, revealing that 57% of its total mass degraded within 80 days. In this context, it was determined that the degradation of the biofilm did not significantly affect soil pH or the levels of macro- and microelements. Based on its physicochemical properties, the obtained biofilm demonstrates high potential for application in the agro-industrial sector as a mulching film, as well as in the production of food packaging materials and bioplastics.
K. Akatan, A. Battalova, Nazym Sagiyeva et al.· Engineer· 0 citations
This work presents a feasible strategy for developing multifunctional PLLA-based materials, demonstrating promising potential for use in active food packaging, wound dressings, and antimicrobial textiles.
Weijun Wu, Zhiyong Yao, Lei Ling et al.· BioNanoScience· 0 citations
