Review
Open access
From amyloid PET to plasma biomarkers: A multimodal imaging framework for early diagnosis and staging of Alzheimer's disease
Jia-Yu Liu
Chou Xu
Yu-Xin Wang
Jun-Feng Zhang
Rui Hui
Wen-Ying Lv
Ao-Xi Xu
Yuan-Yuan Dang
Schichao Su
Hu-Lin Zhao
Yan Gao
Jian-Ning Zhang
Medicine
Abstract
Alzheimer's disease (AD) is biologically defined by amyloid beta and tau pathology. Available biomarkers enable early diagnosis but differ in targets, accessibility, and utility. This review synthesizes evidence for plasma biomarkers, magnetic resonance imaging (MRI), and positron emission tomography (PET) to develop a pragmatic, stage‐aware framework for early diagnosis and staging.