It is demonstrated that biotransformation‐derived lactones attenuate virulence programs in P. aeruginosa, highlighting their potential as quorum sensing inhibitors for managing biofilm‐associated infections.
Abstract
Natural lactones represent a promising anti‐virulence strategy against Pseudomonas aeruginosa by targeting quorum‐sensing (QS) pathways. In this work, we investigate γ‐caprolactone (Capro), γ‐octalactone (Octa), γ‐decalactone (GDL), δ‐decalactone (DDL), and a laboratory‐generated lactone mixture (Lx) as modulators of QS‐regulated virulence. Treatment with γ‐decalactone and engineered lactone formulations significantly downregulated rhlR expression (∼twofold) and suppressed pyocyanin and rhamnolipid production. At 48 h, lactone exposure reduced extracellular virulence factors by up to 74.81% (pyocyanin) and 49.08% (rhamnolipids), indicating effective disruption of quorum sensing signaling. Collectively, these findings demonstrate that biotransformation‐derived lactones attenuate virulence programs in P. aeruginosa, highlighting their potential as quorum sensing inhibitors for managing biofilm‐associated infections.
Background/Objectives: The rapid emergence of antimicrobial resistance (AMR) among pathogenic bacteria has necessitated the development of alternative therapeutic strategies that target bacterial virulence rather than cell viability. Methods: In this study, the flavonoid myricetin was systematically evaluated for its a...
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The rise of multidrug‐resistant (MDR) bacteria poses a serious global health threat.
Pseudomonas aeruginosa
employs quorum sensing (QS) to regulate virulence, making QS inhibition a promising anti‐virulence strategy. Here, 4,687 plant‐derived natural compounds were computationally screened against PqsR, a key tra...
Aziz Mandsaurwala, Renitta Jobby, Vinothkannan Ravichandran· ChemistrySelect· 0 citations
Pseudomonas aeruginosa employs quorum sensing (QS) to coordinate biofilm formation and virulence factor expression, positioning QS as a promising target for anti-infective interventions. This study evaluated the antibiofilm and antivirulence efficacy of 2-methoxy-1,4-naphthoquinone (MNQ), a natural naphthoquinone, agai...
The potential of mushrooms as a source of novel QSIs is discussed, as reflected in their diverse bioactive compounds, multidirectional mechanisms of action, species-specific activity, and synergistic interaction with conventional antibiotics.
S. C. Karunarathna, Wen-Hua Lu, N. Patabendige et al.· Chiang Mai Journal of Scienc...· 0 citations
Daidzein and genistein serve as effective adjuncts to conventional antibiotics, exerting multifaceted actions against P. aeruginosa infection, implying a protective effect on host tissues through PPAR-γ activation.
