Nonantibiotic-Dependent Photothermal-Chemodynamic Synergistic Antibacterial and Hemostatic Sponge Based on TiB2 Nanosheet-Decorated Gelatin/Sodium Alginate Composites.
A rationally designed composite sponge composed of a highly porous gelatin/sodium alginate (Gel/SA) matrix decorated with titanium diboride nanosheets (TiB2 NSs), which effectively immobilizes TiB2 nanosheets (TiB2 NSs), suppressing nanoparticle leaching and thereby mitigating potential nanotoxicity.
Abstract
Conventional antibacterial materials face challenges in simultaneously integrating efficient antibacterial activity, rapid hemostasis, and high biocompatibility. Herein, we report a rationally designed composite sponge (TGSS) composed of a highly porous gelatin/sodium alginate (Gel/SA) matrix decorated with titanium diboride nanosheets (TiB2 NSs). The TiB2 NSs not only endow the TGSS with efficient near-infrared (NIR)-triggered photothermal conversion for localized thermal ablation of bacteria but also confer Fenton-like catalytic activity that converts endogenous H2O2 into cytotoxic hydroxyl radicals (·OH), enabling selective oxidative damage to microbial cells. Owing to photothermal-chemodynamic synergy, TGSS achieves exceptional antibacterial performance with 99.09% inhibition against Escherichia coli (E. coli) and 99.99% against Staphylococcus aureus (S. aureus) under NIR irradiation. Concurrently, the highly porous Gel/SA scaffold promotes rapid blood coagulation via intrinsic pathway activation and physical adsorption, resulting in significantly reduced bleeding time and blood loss. Importantly, the polymeric matrix effectively immobilizes TiB2 nanosheets (TiB2 NSs), suppressing nanoparticle leaching and thereby mitigating potential nanotoxicity. Furthermore, TGSS demonstrated favorable biocompatibility, as evidenced by a hemolysis rate below 5% and cell viability maintained above 90% after 48 h in cytotoxicity assays. Collectively, TGSS effectively prevents bacterial infection and accelerates blood coagulation, showcasing significant potential as a multifunctional wound dressing.
This work demonstrates a safe and effective strategy for combating MDR infections through the combined action of photothermal therapy and nanozyme catalysis, offering promising potential for clinical wound management.
Weiwei Zhang, Lixiang Fan, Xuanjun Zhang et al.· ACS Applied Materials and In...· 0 citations
Synchronously achieving rapid hemostasis and sustained healing remains a central challenge in clinical hemostatic materials. Herein, a multifunctional nanocellulose-based hemostatic sponge (DMTC) was fabricated by using aldehyde-functionalized nanocellulose grafted with madecassoside as the matrix, incorporating MXene immobilized copper nanoparticles. The synergistic interaction between them endowed the sponge with exceptional sustained-release capability, achieving cumulative release rates of 88.8% (MA) and 5.4% (CuNPs) over 7 days, respectively. Furthermore, the inorganic-organic interfacial bonding between nanocellulose and MXene constructed a longitudinally interlaced network structure and the multi-level pore size distribution within the sponge, further enhancing its rapid hemostatic performance (2 s in vitro) and controlled release of bioactive factors. Notably, the DMTC sponge exhibited outstanding antibacterial activity, significantly inhibiting the growth of S. aureus (99.99%) and E. coli (99.99%). Additionally, the DMTC sponge achieved a wound closure rate of 95.96% within 14 days in a mouse model and excellent biosafety and biodegradability, which was significantly superior to the commercially available polyvinyl alcohol sponge. This study has expanded the application of two-dimensional materials, nano-active factors and nanocellulose in hemostatic sponges, which have broad application prospects in clinical hemostasis.
Xiaochen Chang, Fengyuan Xie, Qi Wang et al.· International Journal of Bio...· 0 citations
A pioneering near-infrared activated antibacterial EPLGA/OHADA@HMCuS hydrogel was formulated by doping hollow mesoporous copper sulfide (HMCuS) into the three-dimensional spatial network structure formed between gallic acid-modified ε-polylysine (EPL-GA) and dopamine-engineered and oxidized hyaluronic acid (OHADA) and showcased favorable biocompatibility, sustaining cellular viability.
N. Wang, Wei Jiang, Feiyu Lu et al.· Biomaterials Advances· 0 citations
In vivo studies using an infected wound model demonstrated that the CG/BZC sponge significantly promotes tissue regeneration and accelerates wound healing, providing a promising and versatile approach for designing smart responsive dressings for advanced wound care.
Lanling Xiu, Zhitong Xu, Yueguang Fang et al.· Journal of materials chemist...· 0 citations
This work presents an externally triggered multifunctional therapeutic platform that integrates photothermal bacterial eradication with antioxidant regulation, providing a promising strategy for chronic wound management.
Infected burn wounds are characterized by bacterial invasion, oxidative stress, and persistent inflammation, which severely impair tissue regeneration. Herein, we report a crosslinker-free, hydrogen-bonded cationic guar gum hydrogel (CBBM) co-loaded with berberine (BBR) and MnO2-coated black phosphorus nanosheets (BPNS@MnO2) for the microenvironment-adaptive treatment of infected burn wounds. The dynamic guar gum network endowed the hydrogel with injectability, self-healing ability, and conformal adaptability. BPNS@MnO2 exhibited pH-dependent enzyme-like activities, including OXD-like antibacterial activity under acidic conditions and SOD-/CAT-like ROS-scavenging activity under near-neutral conditions and endowed the hydrogel with NIR-triggered photothermal responsiveness. Moreover, NIR irradiation further enhanced the antibacterial efficacy and moderately enhanced BBR release from the hydrogel. In vitro, CBBM combined with NIR irradiation achieved potent antibacterial efficacy against S. aureus and E. coli under the tested conditions and reduced intracellular ROS levels. In vivo, the CBBM + NIR treatment accelerated infected burn wound healing, achieving a wound closure rate of 97.53 ± 2.01% by day 14, accompanied by reduced inflammation, enhanced collagen deposition, and increased expression of the angiogenesis-related markers VEGF and CD31. These results demonstrate that the CBBM hydrogel is a promising multifunctional guar gum-based dressing for infected burn wound healing by integrating local drug delivery, catalytic regulation, and photothermal activation.
Ziyi Zhao, Yanxiang Sang, Benyan Zheng et al.· International Journal of Bio...· 0 citations
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