Factors Associated with Prescription-to-Vaccination Conversion and Timeliness: A Real-World Analysis

Analysis of the current status and influencing factors of influenza vaccination among medical staff in multiple regions of China.

Background: This study investigated influenza vaccination coverage and its predictors among medical staff in multiple Chinese regions to develop targeted vaccination promotion measures.Methods: A cross-sectional questionnaire survey was conducted on medical workers from Beijing, Hebei, Hunan, Shaanxi, Yunnan and other provinces. Questionnaires collected demographic information, influenza/vaccine knowledge, personal and family vaccination history, and vaccine-related health beliefs. We calculated intra-class Correlation Coefficient (ICC) to evaluate hospital clustering due to nested data, adopted binary logistic regression as primary analysis, and applied two-level multilevel logistic regression to correct biased standard errors for robustness.Results: 476 valid questionnaires were retrieved from 483 distributed ones (98.6%). ICC = 0.021 suggested negligible hospital clustering, and the overall vaccination rate was only 16.4% (78/476). Multivariate analysis identified three positive predictors: vaccine training (OR = 2.503, 95% CI 1.337-4.686), family influenza infection (OR = 2.606, 95% CI 1.338-5.076) and family vaccination (OR = 8.266, 95% CI 4.100-16.663). Perceived barriers negatively predicted uptake (OR = 0.589, 95% CI 0.452-0.767). Staff in primary hospitals had higher coverage than those in tertiary hospitals (OR = 3.640, 95% CI 1.420-9.333).Conclusion: The overall influenza vaccination rate among medical staff remains relatively low. To increase the vaccination rate, in addition to strengthening professional training on influenza vaccine-related knowledge, it is also essential to optimize vaccination accessibility and foster a positive social and occupational vaccination atmosphere. Meanwhile, based on the health belief model of influenza vaccination, targeted health education should be carried out by focusing on reducing perceived barriers and improving health beliefs, so as to effectively enhance the influenza vaccination status of medical staff.

Economic evaluation of alternative PCV13 vaccination strategies in Guangxi, China: a decision tree-Markov model study.

BACKGROUND Pneumococcal disease remains a major cause of morbidity and mortality among children under five years of age, particularly in settings with low vaccine coverage. In China, the 13-valent pneumococcal conjugate vaccine (PCV13) is not included in the National Immunization Program (NIP), resulting in suboptimal uptake. This study evaluated the health and economic impact of including PCV13 in the immunization program in Guangxi Zhuang Autonomous Region. METHODS A decision tree-Markov model was used to simulate a birth cohort of 420,000 children over a 5-year horizon from a societal perspective. The current self-paid vaccination strategy was compared with NIP inclusion. Outcomes included costs, cases, deaths, quality-adjusted life years (QALYs), incremental cost-effectiveness ratios (ICERs), and benefit-cost ratios (BCRs). Costs and outcomes were discounted at 3%. One-way and probabilistic sensitivity analyses were conducted. RESULTS NIP inclusion increased vaccination coverage from 5900 to 417,019 children and was projected to prevent 77,042 cases and 327 deaths over 5 years. Despite higher vaccination costs, reduced disease burden resulted in a net economic benefit of USD 3.92 million (BCR: 1.03). The program generated an additional 25,702.2 QALYs, with an ICER of USD 6042.75 per QALY gained, below the per capita GDP threshold. Probabilistic sensitivity analysis showed that most simulations were below the willingness-to-pay threshold, with the probability of cost-effectiveness approaching 100%. CONCLUSIONS Including PCV13 in Guangxi's immunization program is highly cost-effective and likely to yield positive economic returns. These findings are robust and support policy decisions on PCV13 inclusion.

Classification of scenarios based on the determinants of childhood vaccination coverage in Brazil

Factors Associated With COVID-19 Primary and Booster Vaccine Uptake Among New York City Public School Students.

Level of Compliance with the Vaccination Scheme in Children Under 1 Year

Background: Childhood vaccination is one of the most effective public health interventions for preventing infectious diseases and reducing infant morbidity and mortality. Despite the availability of national immunization programs, incomplete or delayed vaccination schedules remain a major challenge, particularly in low-resource settings. Parental misconceptions, vaccine hesitancy, limited access to healthcare services, and socioeconomic factors contribute to poor vaccination adherence. Objective: To determine the level of adherence to the vaccination schedule among children younger than one year of age. Materials and Methods: A descriptive, observational, cross-sectional, prospective study was conducted. Vaccination records from 260 children under one year of age were reviewed to evaluate adherence to the national immunization schedule. Vaccination status was classified according to predefined adherence categories based on the completeness and timeliness of the recommended vaccines. Results: Among the 260 children included, 141 (54.2%) demonstrated significant non-adherence to the vaccination schedule, whereas 119 (45.8%) showed poor adherence. Overall, adherence to the recommended immunization schedule was below expected levels. Conclusions: Adherence to the vaccination schedule among children younger than one year was insufficient. These findings highlight the need to strengthen educational interventions for parents, improve access to vaccination services, and implement strategies that promote timely childhood immunization in primary healthcare settings.

Factors associated with COVID-19 booster dose uptake in the Jazan region, Saudi Arabia: insights for policy improvement during pandemics

This study aimed to assess factors associated with COVID-19 booster dose uptake in the Jazan region, Saudi Arabia. A sample of 467 individuals participated in a cross-sectional online questionnaire between February and March 2022. Data were investigated using descriptive characteristics, Pearson's chi-square, and logistic regression tests. Nearly 69.6% of respondents believed the booster dose to be necessary, while 16.3% disagreed, and 14.1% were unsure. Almost two-thirds (61.7%) of the respondents had received the booster dose, while 7.9% had booked a vaccination appointment; the remaining 30.4% had neither received nor scheduled any appointments. Furthermore, 57% of non-vaccinated respondents (n=102) planned to receive the booster dose, 19.0% did not plan to receive the vaccine (n=34), and the remaining 24.0% were hesitant (n=43). Receipt of the booster dose of the vaccine was associated with the respondents' attitude, gender, and having not been previously diagnosed with COVID-19 ( P < 0.05). Men were significantly more than twice as likely to receive the booster dose compared to females, while individuals who had positive attitudes toward the booster dose were up to 5 times more likely to be vaccinated. The COVID-19 virus and similar viruses continue to be a possible health risk due to the potential emergence of new, severe variants in the future. Understanding vaccine hesitancy can help manage the acceptance of booster doses and guide the development of targeted awareness campaigns for future disease outbreaks.