Research Paper Comparison of S2 Subunits of the Spike (S) Glycoprotein From Different Strains of SARS-Cov-2 (COVID-19), Aiming to Understand the S2 Role in Virus Transfection Which May Help Its Harness
3D models of the SARS-CoV and SARS-CoV2 spike-proteins (S-protein) were constructed, analyzed, and evaluated using the SARS-CoV spike-structure (PDB No.5X58) as a reference and a unique insertion in the S2 region of COVID-19 may enhance the virus’s ability to target cells that express the appropriate proteases and receptors.
Protein palmitoylation is a two-edged sword in regulating Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. On the one hand, SARS-CoV-2 hijacks the host’s palmitoyl transferases (ZDHHC5/9/20) to modify its spike protein (S protein), enhancing its stability, membrane anchoring, and fusion, conseque...
It is found that the mutations induce distinct transcriptional and translational alterations: rN-Alpha drives a stealth-like infection characterized by sustained translation efficiency and specific evasion of the 2’-5’-oligoadenylate synthetase (OAS) innate immune sensor, whereas rN-Delta and rN-BA trigger a highly ele...
J. Berger, Jonas Schröder, Timothy K. Soh et al.· bioRxiv· 0 citations
Variants of the SARS-CoV-2 virus continue to evolve. Rapidly emerging mutations, particularly in the Spike glycoprotein, may increase transmissibility and infectivity, and also lead to evasion of the immune response. The Spike protein contains two immunodominant epitopes: NTD and RBD. Numerous neutralizing antibodies a...
E. Ermolaeva, A. D. Fomina, A. Zyrina· Frontiers in Microbiology· 0 citations
Enteroviruses are among the most common viral pathogens in humans, causing illnesses ranging from the common cold to severe and sometimes life-threatening diseases such as acute haemorrhagic conjunctivitis or poliomyelitis. To replicate efficiently within host cells, enteroviruses hijack several host factors, including...
Vladimira Horova, Michala Zgarbová, M. Klíma et al.· Antiviral Research· 0 citations
BACKGROUND
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, results in severe acute respiratory illness and has been declared a global public health emergency. Developing effective therapeutic strategies to control the infection remains an urgent priority. The viral spike glycoproteins and proteases play crucial...
Aakrshit Singh, Gaurav Krishna, Shilpi Sonker et al.· Current Organic Synthesis· 0 citations
The high infectivity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) stems from the insertion of four distinct amino acid residues (RRAR), called polybasic cleavage site in the spike (S) protein, that is strikingly identical with that of epithelial sodium channel (ENaC), both of which can be cleaved b...
T. Wang, Yun-Mei Fu, Jin-Peng Wang et al.· Cell Biology and Toxicology· 0 citations
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