Readiness stress-testing of medical AI is extended to open-ended clinical conversation under missing information, where safe behavior means recognizing absent information and qualifying, clarifying, or not over-committing - and where the evaluator becomes part of the measurement.
Abstract
Readiness stress-testing of medical AI has focused on closed-ended and multimodal benchmarks. We extend it to open-ended clinical conversation under missing information, where safe behavior means recognizing absent information and qualifying, clarifying, or not over-committing - and where the evaluator becomes part of the measurement. We stress-test four models - three flagships (Claude Opus 4.8, GPT-5.5, Grok 4.3) and one mid-tier model (Gemini 3.5 Flash) - by deleting the latter half of the final user turn in HealthBench conversations, grading responses with a four-provider LLM-judge panel and a blinded clinician-anchored reference. Two evaluator-facing results are robust. First, judge choice materially changes apparent safety: inter-judge agreement is only moderate (Fleiss'kappa = 0.65), and after adjusting for each judge's general leniency (vote-level logistic regression), a positive same-provider association remains (exact permutation p = 0.04; GPT-5.5 ~ +0.10 on the probability scale) - large enough to change which model appears to over-commit least once its own-provider judge is excluded. Second, LLM judges are more permissive than clinicians on a blinded 50-item subsample: all four are significantly more lenient than the stricter independent clinician (crediting appropriate uncertainty on 66-84% of items vs 52%), and three of four than the author-influenced consensus (Grok directional only; judge-vs-consensus kappa = 0.20-0.43). On the author-audited clinical-underdetermined subset the permissiveness gap widened and the point-estimate model ordering held. A closed-ended MedQA anchor confirms accuracy is high and option-order effects are within a +/-5-point equivalence region for three of four models, so the safety gap is about calibration, not knowledge. We release the harness, prompts, per-item outputs, judge panel, perturbation audit, and human-annotation protocol.
LLM-judged clinical safety effects should be reported as directional and relative, anchored to human review and evaluated jointly with helpfulness, not as calibrated absolute rates.
Overall, while LLM-judges show promise, their inability to handle linguistic and cultural context is a critical limitation, underscoring the need for further investment in scalable evaluation solutions.
G. Williams, S. Rutunda, Floris Nzabakira et al.· npj Digital Medicine· 1 citation
Bottom-up incremental scoring showed the closest alignment with human assessment in clinical AI evaluation, underscoring the need for standardised prompt architectures in clinical AI evaluation.
It is suggested that trustworthy clinical decision support should be evaluated by both average correctness and stability across medically equivalent patient narratives.
No evaluated tool or combination was sufficiently accurate to enable physician-unassisted triage in this setting of patient-initiated text messages in a multi-state Medicaid population.
Sanjay Basu, Sadiq Y. Patel, Parth Sheth et al.· BMC Medical Informatics and...· 0 citations
Consumer artificial intelligence chatbots are now accessed by hundreds of millions of users seeking health information, yet systematic evaluation of their safety boundary maintenance under real-world caregiver pressure remains scarce. We evaluated PediatricSafetyBench-v2, a benchmark of 600 pediatric health queries comprising 300 authentic caregiver queries sourced from the HealthCareMagic-100k-en physician consultation corpus and 300 matched adversarial variants incorporating six operationalized caregiver pressure patterns, across four consumer AI systems (GPT-4o-mini, Gemini-2.0-Flash, Claude-3.5-Haiku, and Llama-3.1-8B). Safety boundary maintenance was assessed using a validated five-component Safety Composite Score (maximum 15 points; safety-appropriate threshold of 10 or above), validated against independent human raters prior to full-corpus application (mean weighted kappa 0.76; Pearson r = 0.88). The overall safety-appropriate rate was 95.5%. Safety-oriented system prompt deployment improved safety-appropriate rates by 5.9 percentage points across all four models. Counter-intuitively, adversarial caregiver pressure was associated with higher rather than lower Safety Composite Score values for all four models across all ten topic categories and severity levels. False expertise claims were the most vulnerability-inducing pressure pattern, whereas emotional escalation was associated with the highest scores. Consumer AI systems maintain safety boundaries in the large majority of pediatric health interactions. PediatricSafetyBench-v2 is publicly released for longitudinal safety monitoring.
Vahid Zolfaghari· npj Digital Medicine· 0 citations
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