TL;DR
The mechanism involved in ERRα recognition of the TMPRSS2-promoter DNA provides insight into ERRα-mediated transcriptional regulation and development of anticancer drugs against ERRα-driven prostate cancer.
The data indicate that MA4 alone drives aberrantly high expression of only a few target genes, whereas A4M counteracts this detrimental effect, and suggests that A4M is crucial through its chromatin-opening activity, which strongly expands the pool of MA4 target genes and thereby promotes the establishment of pre-leuke...
It is suggested that PRMT5 inhibition by CMP5 is associated with reduced TNBC cell viability, impaired migration, increased expression of apoptosis-associated regulators and enhanced apoptotic cell death as measured by Annexin V/PI analysis in vitro.
The role of RBM47 in other genes that contain AREs and GREs, such as apoA-II, ABCA1, HMGCR, IFN-γ, IL-15, low-density lipoprotein receptor, oxidized low-density lipoprotein receptor 1, and programmed cell death 1 ligand 1, is unclear is unclear.
This perspective brings together multiple observations concerning the regulatory architecture and functional interactions of the TP53 gene and its isoforms to cooperate to maintain an open chromatin state in the P2 region in a manner reminiscent of a neural "associative memory" network.
Butyrophilin-like 9 (BTNL9), a member of the immunoglobulin superfamily containing a bZIP-like domain, has a poorly defined role in cancer. Here, we identify BTNL9 as a non-canonical transcriptional regulator and investigate its function in non-small cell lung cancer (NSCLC). Coiled-coil prediction, native PAGE, and co...
Insight is provided into IRES-mediated translation of Δ160p53, which can be considered a novel target for cancer treatment and its role in cancer regulation.
We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.
