Findings highlight the relevance of episodic memory performance as a predictor of biomarker progression, particularly p-tau217, and support its close association with clinical status and disease progression, and the development of screening strategies to identify DS individuals at high risk of rapid cognitive decline.
BACKGROUND
Demonstrating the specificity of plasma biomarkers to AD-related neurodegeneration would add support to their prognostic and diagnostic clinical use.
METHOD
Participants from the Baltimore Longitudinal Study of Aging were cognitively unimpaired at the time of their plasma Aβ42/Aβ40, GFAP, NfL (Quanterix Ne...
Murat Bilgel, Ishaan Shah, Jasmine M. Cooper et al.· Alzheimer's & Dementia· 0 citations
Background and Objectives Adults with Down syndrome (DS) have an increased risk of developing early Alzheimer disease. While our previous cross-sectional study investigated the blood proteome in the context of Alzheimer in DS, identifying CBLN4, CD14, C-X-C motif chemokine 17 (CXCL17), ectodysplasin A2 receptor (EDA2R)...
Olivia Wagemann, Georg S. Nuebling, K. Sandkühler et al.· Neurology· 0 citations
Background Frailty is characterized by declining homeostatic reserves and increased vulnerability to stressors, and has been associated with cognitive decline and dementia. Objective To examine the relationship between frailty, Alzheimer's disease (AD) biomarkers, and cognitive performance in individuals with mild cogn...
Manuela Pintus, M. Valletta, L. Sacchi et al.· Journal of Alzheimer's Disea...· 0 citations
Cognitive impairment is a common and disabling non-motor manifestation of Parkinson’s disease (PD). Early identification of patients at high risk remains challenging, and the metabolic mechanisms underlying cognitive decline are not fully understood.
We conducted a retrospective cohort study including PD pat...
Zi-Kai Zhou, Jie Liu, Li-Juan Wang et al.· Frontiers in Aging Neuroscie...· 0 citations
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