Aug 2026· Acta Pharmacologica Sinica· 0 citations· 41 references
Medicine
TL;DR
It is established that stevioside repairs cholestatic injury by directly driving region-restricted hepatocyte proliferation via YAP signaling, highlighting its potential as a mechanistically innovative candidate for the treatment of cholestatic liver diseases.
Liver cirrhosis represents the irreversible end‐stage of various chronic liver diseases, whereas hepatic fibrosis, characterized by hepatic stellate cell (HSC) activation, constitutes the critical pathological intermediate in this progression. In this study, we investigated the antifibrotic effects of loganin, a natura...
Xinwen Li, Hui-Ling Zhang, Chao Zhang et al.· Mediators of Inflammation· 0 citations
It is confirmed that Lut directly targets PI3K to initiate the PI3K/AKT signaling cascade, and thereby suppresses bile acid-induced hepatocyte apoptosis, and refine the mechanistic understanding of Lut’s hepatoprotective action.
Xing-Liang Zhao, Ying Xu, Hong-Yan Liang et al.· Frontiers in Pharmacology· 0 citations
The data indicate that this pharmacological restoration of lysosomal proteostasis engages key transcriptional regulators (Mediator complex) leading to the selective remodeling of pro-fibrotic and inflammatory pathways, leading to the selective remodeling of pro-fibrotic and inflammatory pathways.
INTRODUCTION
Liver fibrosis, a key pathological step preceding cirrhosis, is characterized by the abnormal accumulation of extracellular matrix (ECM) components, a process largely driven by hepatic stellate cell activation and persistent chronic inflammation. Chlorogenic acid (CGA), a natural polyphenolic compound, has...
Yong-Qing Zhang, Lin Feng, T. Tang et al.· Current Medicinal Chemistry· 0 citations
Saikosaponin D ameliorates NASH by inhibiting the STING-TBK1-IRF3/NF-κB axis in macrophages and promoting M1-to-M2 polarization, identifying SSd as a promising immunomodulatory therapy for NASH.
Wen-Jie Zhang, Yao-Hui Yin, Si-Qi Cheng et al.· Biological and Pharmaceutica...· 0 citations