TL;DR
This chapter examines the strategic architecture of global genomic surveillance, focusing on its application to arboviruses such as chikungunya virus, and explores the integration of genomic data with epidemiological, clinical, and environmental information within a One Health framework.
Molecular technologies have transformed infectious disease surveillance, but their public health value depends on whether molecular signals can be converted into timely and effective action. Unlike molecular epidemiology, which primarily uses molecular variation to characterize distribution, relatedness, transmission,...
Ebola virus disease (EVD) remains one of the most severe viral hemorrhagic fevers, with recurrent outbreaks challenging global healthcare systems. This narrative review traces the evolving epidemiology of EVD from the first recognized outbreaks in 1976 to the ongoing 2026 Bundibugyo virus public health emergency in the...
The evidence is strongest where algorithms perform structured classification against well-curated reference data, notably clade and lineage assignment and resistance determinant detection in taxa with dense phenotype-linked genome collections and confidence weakens progressively for retrospective fitness inference, and...
Endemic and (re)emerging infectious diseases pose a major threat to public health and military readiness in Central and South America. The high biodiversity and the differing transmission pathways require the use of highly sensitive methods to track the emergence and spread of these diseases. High-throughput sequencing...
Mpox has re-emerged as a significant global zoonotic threat, driven mainly by two large waves the 2022 worldwide Clade IIb outbreak and the 2024 Clade Ib epidemic in Central Africa. This review examines the challenges of interpreting this evolving virus from molecular, epidemiological, and bioinformatics perspectives,...
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