It is suggested that the contribution of modifiable lifestyle behaviors and health conditions to the male-female cancer gap varies across populations, underscoring the need for population-specific prevention.
Abstract
Key Points Question Given that cancer incidence is higher among males than among females globally, to what extent do modifiable lifestyle behaviors and health conditions contribute to this disparity by sex across diverse populations? Findings In this multicohort study of 589 766 adults in China and the UK, 11 measured factors jointly accounted for 84% of the male-female gap in non−sex-specific cancer incidence (183 cases per 100 000 person-years) in the Chinese population but only 26% (52 cases per 100 000 person-years) in the UK population. Meaning These findings suggest that the contribution of modifiable lifestyle behaviors and health conditions to the male-female cancer gap varies across populations, underscoring the need for population-specific prevention.
Gender-specific analyses revealed higher tobacco smoking-attributable PAFs in young men and higher obesity-related PAFs in young women, contributing to understanding the distinct etiology of early-onset CRC and highlighting the need for age-specific prevention strategies.
M. S. Seyyedsalehi, P. Boffetta· European Journal of Cancer P...· 0 citations
Background We analysed sex differences in global cancer incidence and mortality using a national development index to better understand how broader socioeconomic factors may contribute to or mitigate sex differences in cancer outcomes. Materials and methods Cancer incidence and mortality data (2012-2017) were obtained...
L. A. Hoveling, B. J. Bergink-Voorthuis, J. R. G. van Vlaardingen et al.· ESMO real world data and dig...· 0 citations
BACKGROUND: Hypertension is the leading risk factor for cardiovascular disease (CVD), with disparities observed by race. Few studies have examined how intersecting social and sex-based biological determinants influence hypertension incidence among parous individuals and across racial groups. The objective of this study...
Jaclyn D. Borrowman, Xuan Cai, Abbi D. Lane et al.· Circulation. Population heal...· 0 citations
Abstract Background Breast cancer remains the most commonly diagnosed cancer and a leading cause of cancer-related mortality among women in Europe, with notable variation across countries. Despite advances in detection and treatment, modifiable risk factors continue to influence disease burden. This study aims to asses...
D. Grad, B. Unim· European Journal of Public H...· 0 citations
In the United States, approximately 282,000 cancer deaths occur annually among women aged ≥30 years, with an estimated 33% attributable to obesity-related cancers (ORCs). Overall, 41% of female cancer deaths are linked to modifiable lifestyle factors, including smoking (24.4%), excess body weight (8.2%), alcohol...
Margaret S. Pichardo, Chen-Hao Lu, L. Jager et al.· Cancer Epidemiology, Biomark...· 0 citations
