Unbiased and scalable reduction of diverse bacterial genomes

Mikel Lipschitz Bai-Yi Quan Indeever Madireddy Gohta Aihara Marisa E. Bennett Tsui-Fen Chou Kai-Hang Wang

Sep 2026 · bioRxiv · 0 citations

Biology

TL;DR

The development and application of Stochastic Lineage-based Iterative Minimization (SLIM) is shown, providing a modular, high-throughput platform for unbiased genome reduction across phylogenetically diverse bacteria and establishing a scalable, generalizable framework for navigating the vast landscape of minimized genomes.

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