Different neuropathological outcomes appear to be driven by distinct genetic variants but converge on shared genes and biological processes related to neuronal structure and communication, as revealed in Alzheimers neuropathology.
These findings identify shared genetic loci between T2D and neurodegenerative dementia, revealing systemic metabolic-neurodegenerative trade-offs and highlighting key genes that underpin the comorbidity, providing a framework for improved understanding of age-related multi-morbidity.
A. Arruda, Archit Singh, O. Bocher et al.· HGG advances· 0 citations
A heteroscedastic personalized regression framework is introduced to move beyond cohort-averaged associations and construct individualized single-nucleotide polymorphism (SNP) profiles for each subject, showing that model-derived individualized SNP-score profiles can reveal latent structure associated with cognitive an...
Neurodegenerative diseases (NDDs) are driven by multiple related yet distinct pathological processes that evolve over decades, resulting in substantial clinical and neuropathological heterogeneity. Postmortem examinations of older individuals frequently reveal multiple coexisting neuropathologies, however, the underlyi...
E. Simmonds, A. Mckeever, U. Yaman et al.· medRxiv· 0 citations
These findings, replicated in four diverse and independent datasets, support imaging-based subtyping as a scalable and clinically translatable approach for capturing heterogeneity in AD pathophysiology and associated cognitive trajectories.
A. Metz, Cassandra Polizzi, R. Moqadam et al.· medRxiv· 0 citations
A practical multi-axis framework comprising clinical phenotype, AD biological context (AD pathology plus co-pathologies and molecular modifiers), network topography (regional patterns) and tempo (rate of clinical and biomarker progression) is proposed to reduce diagnostic mismatches, make cohorts more comparable and su...
L. Grinberg, M. Murray· Nature Reviews Neurology· 0 citations
A genome‐wide association study of tau‐related neurodegeneration identified two novel genetic variants in the loci AKAP9 and STXBP6 leading to higher than expected regional neurodegeneration given the tau level.
F. Nabizadeh, Hanieh Mohamadi· CNS Neuroscience & Therapeut...· 0 citations
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