TL;DR
Nanocarrier-mediated delivery has shown improved pharmacokinetics, enhanced in vivo efficacy, and greater potential for synergistic combination therapies, and greater potential for synergistic combination therapies.
Natural bioactive compounds, especially plant-derived phytoconstituents, have gained significant interest due to their structural diversity, multitarget pharmacological activities, and favourable safety profiles. Their pharmaceutical translation is often hindered by poor aqueous solubility, limited membrane permeabilit...
Phytochemicals have gained remarkable attention because of their broad-spectrum therapeutic activities, including antioxidant, anti-inflammatory, antimicrobial, neuroprotective, and anticancer effects. Despite their pharmacological potential, the clinical translation of many phytochemicals remains limited due to poor a...
Overall, nanocarrier-based strategies offer a promising approach to overcome the limitations of diosgenin, maximizing its pharmacological potential.
Background: Polydatin has shown anti-inflammatory, antioxidant, and cytoprotective effects in preclinical studies. Its development is limited by low oral bioavailability, extensive metabolism, and poorly defined tissue exposure. Objectives: This review summarizes the pharmacology and delivery systems of polydatin, dist...
Plant-derived bioactives offer diverse pharmacological activities, but their development is often limited by poor aqueous solubility, instability, rapid metabolism, and low tissue exposure. This review examines delivery platforms used to address these constraints, including liposomes, solid lipid nanoparticles, nanostr...
Polyphenols are among the most versatile secondary metabolites of plants, with significant therapeutic potential, including anti-inflammatory, cardioprotective, and antioxidant properties. However, limited bioavailability impedes their clinical application. These improvements have led to the use of synthetic stabilizer...
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