This review reframes air pollution as a systemic driver of chronic disease, integrating mechanistic convergence with organ-specific exposure biology and genetic susceptibility, and identifies critical knowledge gaps related to real-world multipollutant exposure, biological resilience, and precision prevention.
Air pollution is a major public health problem worldwide, causing millions of premature deaths every year due to its association with diseases of the respiratory, cardiovascular, neurological, metabolic and carcinogenic systems. A major mechanism of pollutant-induced toxicity has been well identified as oxidative stres...
K. Awasthi, Garima Awasthi, Rajbala Verma et al.· Journal of Xenobiotics· 0 citations
Air pollution remains a global public health challenge, with nearly the global population (99%) breathing air that exceeds World Health Organization (WHO) guideline limits-annual means of 5 μg/m3 for PM2.5 and 15 μg/m3 for PM10. Both household and ambient air pollution are classified as Group 1 carcinogens and contain...
Environmental pollution, a detrimental consequence of industrialization and globalization, is increasingly recognized as a potential risk factor for a wide range of human diseases, including retinal disorders. The retina is particularly vulnerable to environmental stressors, including particulate matter, nitrogen oxide...
Li-Yu Zhang, Qi Tang, E. W. Böhm et al.· Antioxidants· 0 citations
This structured narrative review synthesizes evidence from 37 studies investigating the cellular and molecular mechanisms underlying the impact of environmental mixtures and multipollutant co-exposures on atherosclerosis to highlight emerging mechanistic insights and discuss the relevance of mixture-based approaches fo...
Francesca Gorini, M. Palazzo, L. Simonini et al.· International Journal of Mol...· 0 citations
Reducing air pollution remains the most equitable strategy for slowing biological aging at the population level, and incorporating aging-focused endpoints into environmental health research and regulatory policy is both a scientific and public health priority.
P. Poursafa, J. Jylhävä· Ageing Research Reviews· 0 citations
Ambient air pollutants have been associated with increased risks of mortality and chronic diseases; however, population-based evidence on their shared versus pollutant- and outcome-specific molecular mechanisms remains unclear. Leveraging proteomics data from 48,645 participants in the UK Biobank, we characterized prot...
