Twenty-five sesquiterpene coumarins, including twelve previously undescribed ones, were isolated from the roots of Ferula kuhistanica Korovin and cytotoxic activities of isolates were evaluated.
Abstract
Twenty-five sesquiterpene coumarins, including twelve previously undescribed ones, were isolated from the roots of Ferula kuhistanica Korovin. Their structures were established through comprehensive spectroscopic analysis, NMR, HRESIMS, quantum 13C NMR DP4+ analysis, ECD calculations, and single-crystal X-ray diffraction analysis. This study systematically evaluated the melanogenesis, tyrosinase, anti-inflammatory, and cytotoxic activities of isolates. Kuhistanin B (1) significantly, promoted melanin synthesis (157.8% ± 1.8%) and increased tyrosinase activity (147.9% ± 10.5%) at 50 μM in B16F10 cells. An MTT assay confirmed no significant cytotoxicity at this concentration (cell viability = 100.0% ± 1.6%). In the anti-inflammatory assay, ethyl galbanate (17) and kopeolin (19) showed good activity with IC50 values of 7.1 ± 0.9 and 9.4 ± 3.1 μM. Isosamarcandin (14) and kopeolin (19) exhibited good cytotoxicity against HT-29 cells with IC50 values of 9.82 ± 0.51 and 7.64 ± 0.41 μM, respectively.
A phytochemical investigation of the aerial parts of Euphorbia monostyla Prokh., an endemic species of Turkmenistan, led to the isolation of twelve previously undescribed myrsinane-type diterpenoids, euphomonophanes F-Q (1-12). Their structures were elucidated through comprehensive spectroscopic analyses, including 1D,...
Atabay Kokanov, Hequn Yang, D. Tang et al.· Phytochemistry· 0 citations
ABSTRACT Extraction of the roots of Tripterygium wilfordii afforded ten undescribed dihydro‐β‐agarofuran derivatives [tripterdines M‐V (1–10)], including five sesquiterpene polyesters and five sesquiterpene pyridine alkaloids, along with three known analogues (11–13). Through HRESIMS, spectroscopic analysis (UV, IR, EC...
Ya-Lin Hu, Yi-Ping Xie, Jing-Yi Huang et al.· Chemistry and Biodiversity· 0 citations
To the authors' knowledge, hopearatol A (1) represents the first tetrameric stilbenoid featuring a cyclobutane-containing core embedded within a complex polycyclic framework.
C. N. Nguyen, Phuong T. H. Vo, P. T. Tran et al.· Fitoterapia· 0 citations
In this work, two previously undescribed sesquiterpenes, beilschmiedins A–B (1–2), as well as twelve known compounds (3–14), were obtained from the methanol extract of the Beilschmiedia percoriacea (B. percoriacea) leaves. Their structures were fully elucidated using a combination of spectroscopic techniques, including...
Hieu Tran-Trung, Dau Xuan Duc, Chung Thi Nguyen et al.· RSC Advances· 0 citations
Galeola nudifolia is a medicinal orchid recognized as a valuable source of structurally diverse natural products with potential therapeutic applications. Its chemical composition and biological activities remain largely unexplored, particularly with respect to anti-neuroinflammatory activity. Bioassay-guided investigat...
D. Tran, Bien-Thuy Bui Nguyen, Yuh-Chiang Shen et al.· RSC Advances· 0 citations
Seven previously undescribed compounds (1-7), including two norsesquiterpenes (1 and 3), one cadinane-type sesquiterpene (2), one flavonoid (4), and three xanthones (5-7), along with 17 known analogs (8-24), were isolated from the ethyl acetate extract from the fruits of Hypericum ascyron L. Four pairs of enantiomers (...
Zhang-Rui Liu, Wen-Fei Cai, Bo Wei et al.· Fitoterapia· 0 citations
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