Novel and recurrent TUBB8 variants cause irreversible meiotic spindle defects and refractory ART failure in Chinese women with oocyte maturation arrest.

Xin-Jie Zhuang Yue Li Ying Lian Xin Qiu Na-Na Liu Ying Wang Rong Li Ping Liu

Sep 2026 · Journal of Assisted Reproduction and Genetics · 0 citations · 36 references

Medicine

TL;DR

Routine TUBB8 genetic screening is supported as a valuable diagnostic tool for unexplained recurrent OMA, facilitating early diagnosis, avoidance of futile ART cycles, and personalized reproductive counseling and expands the pathogenic mutational spectrum of TUBB8.

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