Central nervous system and cancer: mechanistic insights and therapeutic opportunities CNS and cancer: a review

Neural–tumor interactions: bidirectional regulatory mechanisms and nervous system-targeted tumor therapeutic strategies

Neural–tumor crosstalk has emerged as a critical frontier in tumor microenvironment research. Central to this field is the dynamic, bidirectional regulatory network between the nervous system and tumor cells that orchestrates malignant progression. This review focuses on tumors arising outside the central nervous syste...

The Brain-tumor axis: Tumor pathogenesis and therapeutic strategies from a cancer neuroscience perspective.

Cancer research has undergone a fundamental paradigm shift, moving beyond a tumor-cell-centric framework toward a systems-level understanding in which the nervous system occupies a central regulatory role. The brain and its peripheral extensions engage in sophisticated, bidirectional crosstalk with tumors across multip...

Neuroimmunology of Oral Cancer: Tumor Progression, Systemic Inflammation, and Neural Circuit Dysfunction from the Cerebellum to the Frontal Cortex

Tumour – nerve interactions in oral squamous cell carcinoma: Mechanisms, clinical implications, and emerging therapeutic targets

Tumour–nerve interactions have emerged as a critical yet underexplored component of cancer biology, particularly in oral squamous cell carcinoma (OSCC). Beyond traditional paradigms cantered on tumour size and stage, accumulating evidence demonstrates that neural elements actively contribute to tumour initiation, progr...

Neuronal regulation of cancer: Mechanisms, functional consequences and therapeutic opportunities.

Current knowledge of neuronal regulation in cancer across three layers is summarized: direct synaptic communication, neuron-derived paracrine signaling, and neuroimmune modulation, and a translational framework is proposed to bridge basic discoveries with clinical application.

Cancer Neuroscience: Establishing a home in Neuro-Oncology.