Phenotypic shift of astrocytes from A1 to A2 induced by fasudil improves demyelination recovery in cuprizone-treated mice

Kun Xu Ting Yang Hao-Ran Dong Tai-Song Yin Jun-Jun Yin Li-Juan Song B. Xiao Jin-Zhu Yin Chun-Sheng Liu Cun-Gen Ma Xin-Yi Li Zhi-Bin Ding

Sep 2026 · Metabolic brain disease · Vol 41 · 0 citations · 36 references

Medicine

TL;DR

FSD is identified as a promising therapeutic candidate for inhibiting demyelination through the regulation of AST polarization via specific signaling mechanism and ameliorated CPZ-induced demyelination.

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