Multifaceted evaluation of novel Co(II), Ni(II), and Cu(II) metal complexes: a promising approach for DNA interaction, antimicrobial, antioxidant, anticancer, and ADME studies

Novel Mixed-Ligand Co(II), Ni(II), and Cu(II) Complexes of Azo-Schiff Bases with 1,10-Phenanthroline and Metformin: Synthesis, Characterization, Molecular Docking, and Antibacterial Evaluation

In this study, two azo-Schiff base ligands were synthesized via condensation of vanillin and 4-(dimethylamino)benzaldehyde with 4-aminoazobenzene. Mixed-ligand complexes of Co(II), Ni(II), and Cu(II) were synthesized using 1,10-phenanthroline (Phen) and metformin (Met), affording twelve complexes with a metal-to-ligand...

Metal–Ligand Engineering of Ru(III), Cu(II), Ni(II), and VO(II) Complexes Featuring a Homopiperazinyl Bis-Phenolate Scaffold: From Physicochemical Properties and structural elucidation to Pharmaceutical Applications

Preparation, Characterization, and Studying the Biological Effect of Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Hg(II), and Au(III) Complexes Derived from New Azo Compound

The present investigation employs a comprehensive molecular docking analysis to assess the binding energies of anticancer drugs, thereby elucidating their binding affinity towards the receptor, and indicates that the gold complex has a strong affinity for the protein kinase (1HK7).

Synergistic enhancement of antimicrobial, anticancer, and catalytic activities in novel Cu(II) and ZrO(II) heteroleptic complexes featuring a benzohydrazide schiff base and 1,10-phenanthroline.

The construction and comprehensive characterization of heteroleptic metal chelates derived from N-(1-(pyridin-2-yl)ethylidene)benzohydrazide and 1,10-phenanthroline with Cu(II) and ZrO(II) ions, respectively, were characterized by alternative techniques, in addition to density functional theory (DFT) calculations.

Integrated experimental and theoretical investigation of Cu(II), Mn(II), and Sr(II) chelates of an indole-based hydrazide derivative: synthesis, structural characterization, molecular docking, DFT studies, and biological evaluation.

Schiff base ligands and their coordination complexes are of significant interest due to their structural versatility and therapeutic potential. In this study, a novel Schiff base ligand, (Z)-N'-((1H-indol-3-yl)methylene)isonicotinohydrazide (HL), was synthesized with a 93% yield via the condensation of 4-pyridinecarbox...

Structural diversity of new mixed-ligand Ni(ii) complexes derived from ciprofloxacin and 2-methylbenzimidazole: synthesis, characterization, DFT insights, antimicrobial activity and DNA gyrase B (4DUH) docking

A set of mixed ligand nickel(ii) complexes, namely, NiAC ([Ni(CIP)(MIM)(OAc)]), NiPE ([Ni(CIP)(MIM)(H2O)]ClO4), and NiCL([Ni(CIP)(MIM)(H2O)2Cl]), derived from the combination of ciprofloxacin (CIP) and 2-methylbenzimidazole (MIM), were synthesized in high yields (85–88%) and characterized by various physicochemical as...