Role of Fiber Orientation in Atrial Arrhythmogenesis

Electrophysiological Remodeling in Chronic Mitral Regurgitation: Underlying Substrates for Atrial Fibrillation.

OBJECTIVE Atrial fibrillation is commonly associated with mitral regurgitation (MR). Using a canine model of MR, we studied the electrophysiological substrates driving the inducibility of atrial tachyarrhythmias (ATAs). METHODS Study animals (n = 12) underwent endovascular avulsion of chordae tendineae under echocard...

Mapping the Progression of Atrial Fibrillation Substrate: Insights from Left Atrial Wall Thickness and High-Density Voltage Mapping

Background/Objective: Advances in cardiac computed tomography (CT) now allow high-resolution, three-dimensional reconstruction of the left atrium, enabling precise quantification of left atrial wall thickness (LAWT). However, the relationship between LAWT and electrophysiological properties, particularly as assessed by...

Eikonal-Based Construction of Initial Conditions for Simulating Reentries in Patient-Specific Atrial Geometries

Multiscale Electrophysiological Remodeling in Ischemic Heart Failure: Simulation Analysis of Ventricular Ectopic Activation

These analyses support numerical convergence and parameter-range-specific sensitivity, not biological population variability, and represent conditional cellular remodeling and generic geometry-constrained wave dynamics rather than a causal molecular-to-organ mechanism or individualized arrhythmia prediction.

Spatial heterogeneity of APD under long QT conditions: characterisation and relationship to sinus activation sequence.

Ventricular sites with distinct sinus activation times exhibit different electrophysiological properties which contribute to enhanced spatial heterogeneity of APD under long QT conditions.

Regional electrical differences and arrhythmia in the rat atria: Role of sympathetic nerve distribution and function.

Atrial fibrillation (AF) commonly arises in the left atrial posterior wall (LAPW) and pulmonary veins (PVs). Dysregulated atrial sympathetic control is a central mechanism driving the induction and maintenance of AF. However, regional differences in atrial sympathetic structure and function remain poorly characterised....