A patient-specific left ventricular model of a subject with NICM secondary to acute myocarditis is developed and three representations of the fibrotic substrate are compared to reproduce the spatial location of the clinically identified SCC while maintaining conduction through the channel.
These analyses support numerical convergence and parameter-range-specific sensitivity, not biological population variability, and represent conditional cellular remodeling and generic geometry-constrained wave dynamics rather than a causal molecular-to-organ mechanism or individualized arrhythmia prediction.
The computational efficiency of contemporary multi-scale digital twins used to investigate cardiac arrhythmia is often hindered by the equation system complexity, while the accuracy of predictions depends on the calibration of model parameters and their intricate non-linear relation. Here we employed a robust pipeline...
Jairo Rodríguez Padilla, N. Cedilnik, B. Ly et al.· Chaos· 0 citations
In HCM, higher myocardial T1 at the most hypertrophied segment correlated with worse global LV myocardial strain and LVEF by CMR, and there were significant correlations between segmental native T1 values at the most hypertrophied segment and global longitudinal strain.
G. S. Galvão, Badr Bannan, L. Jiménez-Juan et al.· Journal of Cardiovascular De...· 0 citations
Diabetic cardiomyopathy increases the risk of ventricular tachycardia and fibrillation through ionic and structural remodeling, but whether the reentrant substrate arises from a diffuse slow-conduction (fibrotic) substrate, a focal scar, or from repolarization remodeling remains unclear. Using a three-dimensional monod...
J. Youm· Korean Journal of Physiology...· 0 citations
Background: Myocardial infarction (MI) causes spatially heterogeneous loss of contractility and progressive extracellular matrix remodeling, altering left ventricular mechanics from the acute phase through chronic remodeling. This review integrates current understanding of infarct, border-zone, and remote-myocardial mi...
T. Pandelani, F. Nemavhola· Bioengineering· 0 citations
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