Pseudo-labeling has become a cornerstone of learning from unlabeled data in semantic segmentation. Yet its effectiveness drops sharply in real-world scenarios where strong imaging noise and long-tailed class distributions occur together. We trace this failure to a vicious cycle of pseudo-label degradation. Imaging noise entangles foreground and background features, lowering prediction confidence across all classes, while long-tailed distributions leave tail classes with far fewer training samples and inherently lower confidence. Under fixed high-threshold filtering, these tail-class predictions are systematically filtered out, so they receive no supervision from unlabeled data and thus features keep degrading in subsequent iterations. Critically, noise and long-tail are not independent obstacles but mutually amplifying ones, and addressing either alone is insufficient. To break this cycle, we propose FTC-Seg, a Feature-Threshold dual-Calibration framework built on a standard teacher-student framework. At the feature level, Orthogonal Prototype Reconstruction (OPR) uses a set of learnable orthogonal prototypes to residually purify pixel-wise features, widening the margin between weak foreground targets and noisy backgrounds. At the threshold level, Adaptive Threshold Calibration (ATC) dynamically adjusts class-specific thresholds based on learning difficulty and prediction-distribution bias, rescuing low-confidence pseudo-labels of tail classes from systematic exclusion. Extensive experiments on four public benchmarks spanning three distinct noise modalities show that FTC-Seg achieves strong performance against state-of-the-art methods, with particularly substantial gains on tail classes. Our results establish that jointly calibrating features and thresholds is essential for robust pseudo-labeling under compounded noise and class imbalance.
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