Development of Morin‐Loaded Hydrogel as a Bioactive Platform for Potential Topical Applications: Experimental and Theoretical Analysis of Drug–Polymer Interactions

Sustained Release and Therapeutic Evaluation of Simvastatin‐Loaded Bioglass–Chitosan Gel Formulation for Skin Regeneration and Wound Healing Potential

Findings suggest that the synthesized hydrogel (BSG‐CHI) provides a favorable microenvironment for tissue regeneration and wound management applications.

Development of an Injectable Thermosensitive Chitosan-Based Hydrogel for Localized Rutin Delivery Optimized Using Box-Behnken Design.

ObjectiveThe objective of the present study was to develop, optimize, and evaluate a chitosan (CS)-based hydrogel incorporating rutin for localized drug-delivery.SignificanceRutin, a naturally occurring flavonoid, possesses significant antioxidant, anti-inflammatory, and anticancer properties. However, its therapeutic application is limited due to poor solubility and low bioavailability. The development of a CS-based injectable hydrogel system offers a promising strategy for enhancing localized delivery, improving drug retention, and achieving release at the target site.MethodsA Box-Behnken Design (BBD) was employed for optimization, where CS concentration (A) and β-Gly concentration (B) were selected as critical material attributes (CMAs), and stirring speed (C) was selected as a critical process parameter (CPP). The hydrogel formulations were evaluated based on parameters including gelation time and swelling ratio. Additionally, rheological properties and in vitro drug-release studies were performed to assess formulation performance.ResultsBBD identified an optimized formulation comprising 1.8% w/v CS, 35% w/v β-Gly, and a stirring speed of 460 rpm, which produced a hydrogel with a gelation time of 148 ± 1.1 s and a swelling ratio of 134.45 ± 1.4%. The experimental responses showed close agreement with the predicted values, confirming the robustness of the optimization model. The optimized hydrogel exhibited shear-thinning behavior suitable for injection and achieved approximately 86% cumulative rutin release over 24 h. Drug-release followed the Korsmeyer-Peppas model, indicating a combined diffusion and polymer relaxation mechanism.ConclusionsThe QbD-based BBD approach enabled the efficient optimization of an injectable thermosensitive CS-based hydrogel system for localized delivery of rutin. The formulation exhibited desirable physicochemical and rheological properties along with controlled drug-release behavior. This hydrogel system represents a promising approach for enhancing the therapeutic efficacy of rutin in localized treatment applications.

Design of Plant Oil-Based Cationic Hydrogels for Protein Encapsulation and Controlled Delivery.

Curcumin-loaded chitosan thermosensitive hydrogel with sustained release for periodontal applications: an in vitro evaluation.

The curcumin-loaded chitosan thermosensitive hydrogel showed improved biological performance and sustained release when compared with free curcumin, suggesting its potential as a localized periodontal drug delivery system.

The Role of a Multifunctional Polysaccharide-Based Hydrogel with Biofunctionalized Hyaluronic Acid and Asiaticoside-Loaded Niosomes in Wound Healing.

Stable hydrogel formation with favorable porous architecture, swelling behavior, thermal stability, and homogeneous distribution of nanovesicles was well established and exhibited excellent biocompatibility, hemocompatibility, and enhanced cell-material interactions.

Development and Characterization of a Biocompatible CS-PVA Hydrogel Incorporated into Carica papaya Extract for Biomedical Applications

Background: The objective of this study was to fabricate and evaluate a Carica papaya extract loadedchitosan/polyvinyl alcohol (Cp-CS-PVA) hydrogel and to assess its structural characteristics, release behavior and multifunctional biological activities for potential biomedical and wound-healing applications. Methods: Cp-CS-PVA hydrogel was prepared using a polymer blending and encapsulation approach. Surface morphology was analyzed using scanning electron microscopy (SEM). In vitro release behavior was evaluated to determine drug diffusion kinetics. Biological activities were assessed through DPPH radical-scavenging assay for antioxidant activity, α amylase inhibition for antidiabetic potential and protein denaturation assay for anti-inflammatory activity, with standard compounds used for comparison. Results: SEM analysis revealed a rough and porous surface morphology, confirming successful encapsulation of Carica papaya extract within the chitosan - PVA hydrogel. The hydrogel exhibited concentration-dependent cytotoxicity against SiHa cells with an IC₅₀ value of 24 μg/mL. The formulation showed sustained drug release over 24 hr indicating effective controlled release behavior. The hydrogel also demonstrated strong antioxidant activity, reaching 61.24% radical scavenging at 75 μg/mL, along with moderate antidiabetic and anti-inflammatory potential. Conclusion: The Cp-CS-PVA hydrogel demonstrates favorable physicochemical properties, sustained release behavior and multifunctional bioactivity, highlighting its promise as a bioactive wound-healing material and a potential therapeutic delivery platform. Further mechanistic and in vivo studies are warranted.