Open access

RIG-I–MAVS–NOXA axis coordinates antiviral defense and apoptosis during parahenipavirus infection

Shivani Rajoriya Divya Misra S. Yu Altanzul Bat Ulzii Hennisa Hennisa Tae-Wook Kang Hye Jin Shin Yeonsu Oh Carolina B. López Won-Keun Kim

Aug 2026 · bioRxiv · 0 citations

Biology

TL;DR

It is found that GAKV is primarily detected by the innate immune sensor retinoic acid-inducible gene I, which activates antiviral signaling through the adaptor protein mitochondrial antiviral signaling protein (MAVS) and initiates type I interferon (IFN) responses.

DOI Semantic Scholar

Read PDF

Similar papers

Review Open access Sep 2026

Zika virus and host innate immunity: mechanisms of activation and evasion

This Review summarizes current knowledge of how the innate immune system recognizes ZIKV and how the virus counteracts these responses, while highlighting unresolved questions and potential therapeutic targets.

Dan-Yu Qian, Yu-Lei Guo, Ai-Xin Li et al. · Frontiers in Immunology · 0 citations

Review Open access Aug 2026

Unraveling the Multifaceted Role of TRIM21 in Virus-Triggered Innate Immunity and Diseases

The functional roles of TRIM21 are summarized to provide insights for researchers and inspire further investigation in this area to provide insights for researchers and inspire further investigation in this area.

Shi-Jin Lan, Ying Wang, Yu-Tong Fu et al. · Biomolecules · 0 citations

Review Open access Sep 2026

MERS-CoV accessory ORF proteins in innate immune evasion: an evidence-graded functional framework

Middle East respiratory syndrome coronavirus (MERS-CoV) is a merbecovirus associated with recurrent zoonotic spillover and severe lower-respiratory disease. Research has focused largely on DPP4-mediated entry, spike structure, replicase biology, neutralizing antibodies, and vaccines. However, the 3′-encoded accessory p...

Chun-Hua Wang, Xu-Hang Li, Yi Jiang et al. · Frontiers in Immunology · 0 citations

Open access Aug 2026

PRRSV suppresses FTO-dependent m6A demethylation to reprogram STAT signaling and innate immunity

ABSTRACT RNA viruses have evolved diverse strategies to evade host interferon (IFN)-stimulated gene (ISG) defenses; however, how they exploit host epitranscriptomic regulation remains poorly understood. Here, we identify an immune-evasion mechanism in which porcine reproductive and respiratory syndrome virus (PRRSV) ta...

Yi-Peng Pang, F. M. Amona, Yuan Liang et al. · mBio · 0 citations

Open access Aug 2026

The APC/C subunit APC7 exerts antiviral effects by targeting the adaptor protein MAVS

It is demonstrated that APC7 potentiates the antiviral response through activation of MAVS-mediated signaling, which provides new insights into the regulatory mechanisms of innate immunity and viral infections.

Rui Su, Aiping Sun, Yifan Niu et al. · Frontiers in Immunology · 0 citations

Sep 2026

Black carp DDX3b suppresses antiviral immunity by inhibiting IRF7 modifications and promoting its lysosomal degradation.

Type I interferons (IFNs) serve as pivotal functional molecules in the antiviral immune response of fish, and their signaling pathways require precise negative regulation to avoid tissue damage caused by excessive immune activation. In the present study, DEAD-box RNA helicase 3b (DDX3b), an ATP-dependent RNA helicase i...

Liang Chen, Zi-Ting Zhao, Zhi-Hao Du et al. · Fish and Shellfish Immunolog... · 0 citations