Curcumin nanoformulations for modulating neuroinflammation and oxidative stress in Alzheimer's disease: blood-brain barrier transport, formulation strategies and therapeutic applications.
Parkinson's disease (PD) is a progressive neurodegenerative disorder driven by oxidative imbalance, mitochondrial dysfunction, and persistent neuroinflammation, yet current pharmacological interventions provide symptomatic relief but fail to halt neuronal degeneration largely owing to complex pathological mechanisms an...
Qu-Cheng Huang, Yun-Wei Sun, Yue Duan et al.· International Journal of Bio...· 0 citations
The current knowledge on polyherbal synergy, nanocarrier-based targeting methods, and nose-to-brain delivery strategies to treat neurodegenerative disorders are summarized, highlighting their potential therapeutic applications, underlying mechanisms, translational issues, regulatory factors, and emerging trends such as...
Mahalakshmi Seelam, Varalakshmi Sagili· Drug Delivery Letters· 0 citations
Alzheimer's disease (AD) is the most common form of senile dementia worldwide and is a progressive and irreversible neurodegenerative disorder, which represents a huge socioeconomic burden on modern healthcare systems. The neuropathology of AD is characterised by a very complex, interconnected cascade of cellular event...
V. S, Sarupruthiya M, Jeevitha D et al.· International Journal Of Rec...· 0 citations
Background and Objectives: The main neurodegenerative diseases (NDs)—Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS)—represent a growing global health burden with no available disease-modifying therapies. Curcumin, a polyphenol from Curcuma longa, is...
Alejandra Castelló-Guillen, Marta Garrido-Reig, Jordi Caplliure-Llopis et al.· Pharmaceuticals· 0 citations
Parkinson's disease (PD) is a progressive neurodegenerative disorder marked by the selective loss of dopaminergic neurons in the substantia nigra, which gives rise to characteristic motor and non-motor behavioral impairments. Disease-modifying therapies remain elusive, largely due to the restrictive nature of the blood...