Sep 2026· Journal of materials chemistry. B· 0 citations
Medicine
TL;DR
PEG-stabilized nanoparticle assembly improved the dispersion stability of proanthocyanidin nanoparticles and its distribution within the collagen sponge, thereby enhancing their antioxidant and pro-repair effects.
Persistent inflammation and oxidative stress are central barriers to effective diabetic wound repair. Successful healing requires restoration of a coordinated local microenvironment, yet achieving this remains a major clinical challenge. Herein, a composite ginsenoside Rd-functionalized hydrogel (Gel@Rd) with dynamic a...
Qian-Qian Wu, Yan Li, Xin-Xin Gao et al.· Journal of Controlled Releas...· 0 citations
A composite hydrogel incorporating organic-inorganic peptide-zinc nanoflowers incorporating organic-inorganic peptide-zinc nanoflowers for sustained local delivery regulated the diabetic wound microenvironment through antibacterial, antioxidant, anti-inflammatory, and pro-angiogenic activities, thereby promoting tissue...
Xin Dan, Han Chen, Song-Jie Li et al.· Regenerative Biomaterials· 0 citations
Diabetic wounds are prone to bacterial infection and difficult to heal due to chronic inflammation and hyperglycemic microenvironment. Here we developed a novel bioactive hydrogel with multifunctional tunable properties, including biocompatibility, pH-response, anti-inflammatory activity, and the ability to promote dia...
Zi-Rui Fan, Shi-Xin Wang, Si-Tong Bian et al.· International Journal of Bio...· 0 citations
Diabetic wounds are persistently exposed to pathological microenvironments, such as hyperglycemia and excessive ROS accumulation, which result in insufficient angiogenesis and restricted cell migration, representing a prominent challenge in clinical wound repair. Traditional wound dressings primarily focus on passive c...
Ying Hao, Hao Zhou, Hanif Ullah et al.· Journal of materials chemist...· 0 citations
Background Diabetic burn wound healing is impaired by persistent mitochondrial oxidative stress, chronic inflammation, bacterial infection, and defective tissue regeneration. Although honokiol possesses antioxidant and anti-inflammatory properties, its therapeutic potential is limited by poor local retention. Moreover,...
Min Li, Xue-Dong Yu, Huan-Tao Hu et al.· Frontiers in Pharmacology· 0 citations
Chronic diabetic wounds remain a major clinical challenge due to persistent inflammation, excessive reactive oxygen species (ROS), and impaired angiogenesis. However, many wound dressings do not coordinate therapeutic delivery with the changing oxidative and angiogenic requirements of diabetic wound healing. Herein, we...
Hua-Jian Zhu, Fang-Min Jiao, Peng Wang et al.· International Journal of Bio...· 0 citations
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