Étude de Faisabilité : Production Frugale du Au@C60 (Fullerène Endohédrique à l'Or)

Abstract

Résumé FRCe document, produit avec l’assistance de ChatGPT 5.2 Thinking + Gemini 3 Raisonnement, est publié sous licence Apache 2.0. Il constitue une publication défensive (antériorité) et entre de ce fait dans l’état de la technique au sens des législations applicables : art. 54(2) CBE (Convention sur le brevet européen), art. L 611-11 CPI (Code de la propriété intellectuelle français), 35 U.S.C. §102(a) (loi américaine sur les brevets), Loi chinoise sur les brevets art. 22(5) (中华人民共和国专利法) et Loi japonaise sur les brevets art. 29(1) (特許法). Cette publication divulgue des voies frugales et industrialisables pour synthétiser, purifier, caractériser, formuler et déployer Au@C60 (arc électrique sous hélium, anodes composites, contrôle d’arc, recirculation de gaz, quench/collecte de suie, extraction solvants, formation colloïdale par anti-solvant, gradients de densité, ultracentrifugation batch/continue, recyclage solvants, récupération d’or). Elle divulgue aussi des usages théranostiques (contraste CT, posologie guidée par imagerie), dispositifs (capteurs redox/ROS, pansements photo-activables, coatings d’implants), et briques data/IA (interopérabilité, apprentissage fédéré, MLOps sécurisé, boucle fermée biomarqueurs). Abstract ENThis document, produced with the assistance of ChatGPT 5.2 Thinking and Gemini 3 Raisonnement, is released under the Apache 2.0 licence. It is a voluntary defensive publication (prior art) and therefore enters the prior art upon release under the applicable patent statutes : EPC Art. 54(2) (European Patent Convention), French PC Art. L 611-11 (French Intellectual Property Code), 35 U.S.C. §102(a) (United States Patent Act), Chinese Patent Law Art. 22(5)(中华人民共和国专利法), and Japanese Patent Act Art. 29(1)(特許法). It discloses frugal, industrializable routes to synthesize, purify, characterize, formulate, and deploy Au@C60 (helium arc discharge, composite anodes, arc control, gas recirculation, quench/soot collection, solvent extraction, antisolvent-driven colloid formation, density gradients, batch/continuous ultracentrifugation, solvent recycling, gold recovery). It further discloses theranostic uses (CT contrast, imaging-guided dosing), devices (redox/ROS sensors, photoactivable wound dressings, implant coatings), and data/AI building blocks (interoperability, federated learning, secure MLOps, biomarker closed-loop control). Timestamp: 4ef4283953ef9dac943e0965799c0099ec42acc591d12b5b10ced5e32f0e7fa3SHA-256: 2026-01-01T13:05:21Z Liste des innovations & classification (IPC ; CPC)1. Au-graphite composite anode — IPC C01B 31/02 ; CPC C01B 31/022. Catalytic Ni/Cu co-doping — IPC C01B 31/02 ; CPC C01B 31/023. Assisted He-pressure mapping — IPC G01N 27/62 ; CPC G01N 27/624. Stable-current arc control — IPC H05H 1/24 ; CPC H05H 1/245. Automated feed-through anode — IPC C01B 31/02 ; CPC C01B 31/026. He recirculation with purity — IPC F17C 5/02 ; CPC F17C 5/027. Green extraction via limonene — IPC C07C 29/00 ; CPC C07C 29/008. Antisolvent colloid separation — IPC B01D 21/00 ; CPC B01D 21/009. Density-gradient ultracentrifuge — IPC B01D 21/00 ; CPC B01D 21/0010. Continuous-flow ultracentrifuge — IPC B01D 21/00 ; CPC B01D 21/0011. Temperature-controlled centrifugation — IPC B01D 21/00 ; CPC B01D 21/0012. Solvent recycling with QC — IPC B01D 3/00 ; CPC B01D 3/0013. Gold recovery from residues — IPC C22B 11/00 ; CPC C22B 11/0014. Inline MS+ICP batch release — IPC G01N 27/62 ; CPC G01N 27/6215. TEM Z-contrast validation — IPC G01N 23/00 ; CPC G01N 23/0016. Injectable liposome formulation — IPC A61K 9/127 ; CPC A61K 9/12717. Oral lipid emulsion dosing — IPC A61K 31/00 ; CPC A61K 31/0018. Calibrated CT contrast agent — IPC A61K 49/04 ; CPC A61K 49/0419. Imaging-guided personalized dosing — IPC G16H 20/20 ; CPC G16H 20/2020. Radiosensitization with ROS buffering — IPC A61N 5/10 ; CPC A61N 5/1021. Mitochondria uptake qualification assay — IPC C12Q 1/68 ; CPC C12Q 1/6822. Cationic mitochondrial functionalization — IPC A61K 31/00 ; CPC A61K 31/0023. Redox bioelectronic interface — IPC G01N 27/327 ; CPC G01N 27/32724. Anti-inflammatory CT-visible implant coating — IPC A61L 31/10 ; CPC A61L 31/1025. Photo-activable antimicrobial dressing — IPC A61L 15/00 ; CPC A61L 15/0026. Vitamin E co-formulation — IPC A61K 31/00 ; CPC A61K 31/0027. CoQ10/melatonin synergy stack — IPC A61K 31/00 ; CPC A61K 31/0028. Porphyrin–Au@C60 PDT theranostics — IPC A61K 49/00 ; CPC A61K 49/0029. Gold core with Au@C60 shell — IPC A61K 49/04 ; CPC A61K 49/0430. Au@C60 CT phantom standard — IPC G01T 1/00 ; CPC G01T 1/0031. Pre-analytical soot extraction kit — IPC C12Q 1/68 ; CPC C12Q 1/6832. Au@C60 API purity specification — IPC G01N 27/62 ; CPC G01N 27/6233. Lot–imaging–PK interoperability ontology — IPC G16H 10/60 ; CPC G16H 10/6034. Federated learning across sites — IPC G06N 20/00 ; CPC G06N 20/0035. Secure MLOps dosing pipeline — IPC G16H 20/20 ; CPC G16H 20/2036. ROS biomarker closed-loop infusion — IPC A61M 5/168 ; CPC A61M 5/16837. Inert traceable packaging — IPC B65D 81/32 ; CPC B65D 81/3238. CT calibration-as-a-service — IPC G01T 1/00 ; CPC G01T 1/0039. Safety interlocked arc reactor — IPC H05H 1/46 ; CPC H05H 1/4640. C60 co-product valorization — IPC C01B 31/02 ; CPC C01B 31/0241. Multiobjective yield/purity DOE — IPC G01N 27/62 ; CPC G01N 27/6242. Colloid stability QC index — IPC G01N 15/14 ; CPC G01N 15/1443. Soot pre-treatment by sieving — IPC B01D 35/00 ; CPC B01D 35/0044. Ultrasound-assisted extraction — IPC B01D 11/02 ; CPC B01D 11/0245. Gentle inert vacuum concentration — IPC B01D 3/14 ; CPC B01D 3/1446. C60 fraction crystallization — IPC C01B 31/02 ; CPC C01B 31/0247. Two-stage centrifuge + polishing — IPC B01D 21/00 ; CPC B01D 21/0048. UV-Vis enrichment monitoring — IPC G01N 21/31 ; CPC G01N 21/3149. Recycled-gold KPI tracking — IPC G06Q 10/083 ; CPC G06Q 10/08350. Free-gold maximum specification — IPC G01N 27/62 ; CPC G01N 27/6251. CT–ICP correlated biodistribution — IPC A61B 6/03 ; CPC A61B 6/0352. Organ-threshold dosing rules — IPC A61K 31/00 ; CPC A61K 31/0053. Low-dose CT for Au@C60 — IPC A61B 6/03 ; CPC A61B 6/0354. AI reconstruction for Au quantification — IPC G06N 20/00 ; CPC G06T 11/0055. Automated tumor uptake detection — IPC G16H 30/40 ; CPC G16H 30/4056. Liposome size/charge window — IPC A61K 9/127 ; CPC A61K 9/12757. Sterile filtration compatibility — IPC A61K 9/127 ; CPC A61K 9/12758. Emulsion droplet-size QA — IPC A61K 9/107 ; CPC A61K 9/10759. Safe LED dosimetry for dressings — IPC A61N 5/06 ; CPC A61N 5/0660. Multi-method implant deposition — IPC A61L 31/10 ; CPC A61L 31/1061. Portable ROS QC sensor — IPC G01N 27/327 ; CPC G01N 27/32762. Transdermal antioxidant patch — IPC A61K 9/70 ; CPC A61K 9/70663. Implantable closed-loop pump — IPC A61M 5/168 ; CPC A61M 5/16864. End-to-end lot-to-patient traceability — IPC G16H 10/60 ; CPC G06F 21/6265. Privacy secure HU aggregation — IPC G06F 21/62 ; CPC G06F 21/6266. Optimal RT window scheduling — IPC A61N 5/10 ; CPC A61N 5/1067. Inter-lab proficiency QC sample — IPC G01N 27/62 ; CPC G01N 27/6268. Reuse-grade solvent logistics — IPC B65D 81/32 ; CPC B65D 81/3269. Anti-aggregation API conditioning — IPC A61K 31/00 ; CPC A61K 31/0070. Parametric techno-economic simulator — IPC G06Q 10/06 ; CPC G06Q 10/0671. Sacrificial cathode Au capture — IPC C22B 11/00 ; CPC C22B 11/0072. Tuned quench reactor geometry — IPC C01B 31/02 ; CPC C01B 31/0273. Cold cyclone soot collector — IPC B01D 45/12 ; CPC B01D 45/1274. Free-Au selective membrane filtration — IPC B01D 61/00 ; CPC B01D 61/0275. Free-Au stripping voltammetry QC — IPC G01N 27/26 ; CPC G01N 27/2676. Oxygen exclusion passivation step — IPC G01N 27/62 ; CPC G01N 27/6277. Au@C60 spike recovery QA — IPC G01N 27/62 ; CPC G01N 27/6278. Micro-HPLC analytical polishing — IPC B01D 15/08 ; CPC B01D 15/0879. HU-preserving AI denoising — IPC G06T 5/50 ; CPC G06T 5/5080. Phantom-based drift detection — IPC G01T 1/00 ; CPC G01T 1/0081. Composite response score uptake+ROS — IPC G16H 50/20 ; CPC G16H 50/2082. Mito fraction + TEM proof — IPC C12Q 1/68 ; CPC C12Q 1/6883. LNP lipid nanoparticle carrier — IPC A61K 9/127 ; CPC A61K 9/12784. Gradient-release implant coating — IPC A61L 31/10 ; CPC A61L 31/1085. Dressing with sensor+LED — IPC A61B 5/145 ; CPC A61B 5/14586. PDT patch thermal safety lockout — IPC A61N 5/06 ; CPC A61N 5/0687. Microneedle Au@C60 delivery — IPC A61K 9/70 ; CPC A61K 9/70788. NADH electrochemical sensor — IPC G01N 27/327 ; CPC G01N 27/32789. Inert transport cartridge — IPC B65D 81/32 ; CPC B65D 81/3290. SOP stress-testing for shelf-life — IPC G01N 21/31 ; CPC G01N 21/3191. Smartphone turbidity aggregation QC — IPC G01N 21/88 ; CPC G01N 21/8892. Multi-stream product split planning — IPC G06Q 10/06 ; CPC G06Q 10/0693. Process-to-effect database — IPC G16H 10/60 ; CPC G16H 10/6094. Dynamic consent for CT data — IPC G06F 21/62 ; CPC G16H 10/6095. Conditional release with rework rules — IPC G01N 27/62 ; CPC G01N 27/6296. Low-adsorption sterile filter SOP — IPC A61K 9/127 ; CPC A61K 9/12797. Auto-calibrated CO interlock module — IPC G01N 33/00 ; CPC G01N 33/0098. Bayesian minimal-effective dosing — IPC G16H 20/20 ; CPC G16H 50/2099. Field mode without CT — IPC A61K 31/00 ; CPC A61K 31/00100. Micronized Au supplier qualification — IPC G01N 1/28 ; CPC G01N 1/28101. Xylene high-power extraction — IPC B01D 11/02 ; CPC B01D 11/02102. MeTHF miscible green route — IPC B01D 11/02 ; CPC B01D 3/14103. p-Cymene bio-based solvent — IPC B01D 11/02 ; CPC B01D 11/02104. Multi-stage organic gradients — IPC B01D 21/00 ; CPC B01D 21/00105. Inline density/refraction sensing — IPC G01N 7/06 ; CPC G01N 7/06106. Turbidity cutoff auto-switching — IPC B01D 21/00 ; CPC B01D 21/00107. Low-adsorption centrifuge consumables — IPC B01D 21/00 ; CPC B01D 21/00108. Raman quick ID for Au@C60 — IPC G01N 21/65 ; CPC G01N 21/65109. Isotopic Au ICP calibration — IPC G01N 27/62 ; CPC G01N 27/62110. UV-Vis reference spectrum library — IPC G01N 21/31 ; CPC G01N 2