Rapport d'Expertise Stratégique – Dentifrice « Santé Intégrale »

Abstract

Résumé FRCe document, produit avec l’assistance de ChatGPT 5.1 Thinking et Gemini 3 Pro, est publié sous licence Apache 2.0. Il constitue une publication défensive (antériorité) et entre de ce fait dans l’état de la technique lors de sa mise à disposition au public conformément aux textes applicables : EPC Art. 54(2) (European Patent Convention), French IPC Art. L 611-11 (Code de la propriété intellectuelle), 35 U.S.C. §102(a) (United States Patent Act), Loi chinoise sur les brevets Art. 22(5) (中华人民共和国专利法) et Loi japonaise sur les brevets Art. 29(1) (特許法). Il décrit une plateforme de dentifrices « Santé Intégrale » sans fluor articulée en 30 familles d’innovations : compositions régénératives multi-actifs, nano-hydroxyapatite et verres bioactifs dopés, procédés d’upcycling circulaire et de synthèse basse énergie, lignes industrielles de dentifrice solide, protocoles cliniques oral–systémiques, logiciel de formulation “Safe-by-Design” et kits de déploiement à l’échelle scolaire et populationnelle. Chaque proposition est décrite de manière habilitante, classée en IPC et CPC, avec preuve d’horodatage (RFC 3161 / FreeTSA). Abstract ENThis document, produced with the assistance of ChatGPT 5.1 Thinking and Gemini 3 Pro, is released under the Apache 2.0 licence. It is a voluntary defensive publication (prior art) and therefore enters the prior art upon release under the applicable patent statutes (art. L 611-11 CPI / art. 54(2) CBE), 35 U.S.C. §102(a), Chinese Patent Law Art. 22(5) (中华人民共和国专利法), and Japanese Patent Act Art. 29(1) (特許法). It discloses a fluoride-free “Integral Health” toothpaste platform covering 30 invention families: multi-active regenerative formulations, doped nano-hydroxyapatite and bioactive glass systems, circular upcycling and low-energy synthesis routes, solid toothpaste industrial lines, oral–systemic clinical protocols, Safe-by-Design formulation software, and school- and population-scale deployment kits for low-income countries. Every proposal is described in an enabling manner, classified with IPC and CPC codes, and accompanied by timestamp proof (RFC 3161 / FreeTSA). Timestamp: 2025-12-10T18:22:34ZSHA-256: ac8c629e9b3b0f891d3baf2f593f82ef4d8c3720bf134c82001788b6988e8557 Liste des innovations & classification (IPC ; CPC) [1] Toothpaste “L’Architecte” — IPC A61K 8/34 ; CPC A61Q 11/00 [2] Toothpaste “Le Gardien” — IPC A61K 8/34 ; CPC A61K 8/22 [3] Toothpaste “Le Souverain” — IPC A61K 8/34 ; CPC A61Q 11/00 [4] Sublingual K2 CoQ10 iodine complex — IPC A61K 8/34 ; CPC A61K 9/107 [5] Multi ion doped nano hydroxyapatite — IPC C01B 25/32 ; CPC C01B 25/326 [6] Theobromine functionalised nano HA — IPC A61K 8/34 ; CPC A61K 8/22 [7] Metal enriched zeolite toothpaste — IPC A61K 8/34 ; CPC A61K 8/22 [8] Natural oral chelating complexes — IPC A61K 8/34 ; CPC A61K 8/97 [9] Anhydrous iodinated toothpaste — IPC A61K 8/34 ; CPC A61K 8/02 [10] Eggshell derived nano HA process — IPC C01B 25/32 ; CPC C01B 25/326 [11] Marine shell nano HA process — IPC C01B 25/32 ; CPC C01B 25/326 [12] Fish bone nano HA process — IPC C01B 25/32 ; CPC C01B 25/326 [13] Low temperature doped nano HA synthesis — IPC C01B 25/32 ; CPC C01B 25/326 [14] Concentrated anhydrous solid toothpaste — IPC A61K 8/34 ; CPC A61K 9/20 [15] Doped bioactive glass with peptides — IPC A61K 8/34 ; CPC A61Q 11/00 [16] Gingival CoQ10 vitamin E xylitol complex — IPC A61K 8/34 ; CPC A61Q 11/00 [17] Silver copper zeolite bacteria trap — IPC A61K 8/34 ; CPC A61Q 11/00 [18] Anhydrous enzyme probiotic toothpaste — IPC A61K 8/34 ; CPC A61Q 11/00 [19] Circular nano HA supply chain — IPC C01B 25/32 ; CPC C01B 25/32 [20] Oral systemic clinical protocol and kit — IPC G01N 33/487 ; CPC G01N 33/487 [21] Solid toothpaste line with circular HA — IPC C01B 25/32 ; CPC B29C 43/00 [22] Ultra light logistics packaging — IPC B65D 1/00 ; CPC B65D 1/02 [23] In line K2 CoQ10 microdosing module — IPC B01F 13/00 ; CPC B01F 13/105 [24] Software toxicological firewall — IPC A61K 8/00 ; CPC G16H 50/20 [25] Techno economic model for solid regenerative toothpaste — IPC G06Q 50/20 ; CPC G06Q 50/22 [26] Integrated preclinical toolkit — IPC G01N 33/48 ; CPC G01N 33/483 [27] Ex vivo sublingual K2 CoQ10 cell — IPC G01N 33/15 ; CPC G01N 33/152 [28] Anhydrous toothpaste challenge test — IPC C12Q 1/02 ; CPC C12Q 1/32 [29] Cosmetic to class IIa device pathway — IPC G06Q 50/22 ; CPC G16H 10/60 [30] School based preventive kit for low income countries — IPC A61C 19/00 ; CPC A61C 19/02 Keywords nano-hydroxyapatite toothpaste, self-assembling peptide, fluoride-free, zeolite toothpaste, oral detox, postbiotics, vitamin K2 toothpaste, coenzyme Q10, systemic oral care, sublingual delivery, microcapsules, oral nutraceutical, doped hydroxyapatite, zinc strontium, enamel repair, theobromine delivery, coated hydroxyapatite, controlled release, clinoptilolite, heavy metal capture, silver-doped zeolite, oral chelation, fulvic acid, polyphenols, povidone iodine, anhydrous toothpaste, antiseptic oral care, eggshell hydroxyapatite, waste valorisation, green process, oyster shell, marine hydroxyapatite, circular economy, fishbone hydroxyapatite, biogenic apatite, dental additive, low-temperature synthesis, microwave-assisted, doped nano-HA, toothpaste tablets, waterless formulation, sustainable oral care, solid toothpaste line, circular nano-hap, low-energy process, lightweight packaging, refillable container, logistics optimization, microdosing system, vitamin K2, coenzyme Q10, safe-by-design, oral care formulation, toxicity rules engine, techno-economic model, regenerative toothpaste, public health impact, preclinical screening toolkit, oral systemic toothpaste, sublingual absorption assay, nano hydroxyapatite dentifrice, vitamin K2 microdosing, coenzyme Q10 delivery, anhydrous toothpaste stability, microbiological challenge test, regulatory escalation pathway, class IIa medical device, school dental programme, low income countries, tooth preservation indicator, population oral health, preventive dentistry model