TL;DR
The use of multimodal network therapy to manipulate neurophysiological resilience in thalamocortical and corticocortical circuitry to modulate depression-like phenotypes and relapse in LLD patients is supported.
Depression is a highly prevalent affective disorder, and current pharmacotherapies are often limited by suboptimal efficacy and adverse effects. Diosmetin, a dietary flavonoid, exhibits neuroprotective properties through antioxidant and anti-inflammatory mechanisms; however, its antidepressant potential remains insuffi...
Pruritus is closely associated with anxiety and depression, yet irritability and agitation in chronic itch patients remain poorly characterized in preclinical studies. Using an MC903-induced chronic itch model, we evaluated emotional behaviors across varying durations (7-18 days) and doses (50-100 μM). MC903 induced se...
It is found CRH signaling via CRHR1 indeed disrupts reward behaviors in naïve mice, but is dysregulated in ‘anhedonic’ mice with a history of ELA, and activation of CRH receptor 2 (CRHR2) reverses anhedonia-like behaviors in adult ELA mice.
Background Adolescence is a critical window for autonomic and limbic development and a period of elevated risk for depression. Although autonomic and limbic system function have, independently, been linked to depression, they are coupled and both influenced by early life stress (ELS). We do not yet know, however, wheth...
The mPFC is a critical hub for CIH-induced cognitive impairment, and its targeted inhibition can restore cognitive and synaptic function, however, sleep architecture disruptions are governed by distinct mechanisms, indicating a dissociation between CIH-mediated cognitive and sleep pathologies.
By restoring neurotrophic signaling and dopaminergic function, PT320 represents a promising therapeutic strategy for PD-related anxiety and depression by restoring neurotrophic signaling and dopaminergic function in the nucleus accumbens.
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