Tectorigenin alleviates HFpEF by targeting the EGFR-EGR2-Acot1 axis to improve myocardial lipid metabolism.

Gentiopicroside Regulates EGFR and Induces Its Lysosomal Degradation to Attenuate Heart Failure.

Cardiac hypertrophy is a major pathological response to cardiovascular stress and a critical contributor to heart failure (HF). Gentiopicroside (GPS), a naturally occurring iridoid glycoside derived from Gentiana scabra, exhibits anti-inflammatory, antioxidant, and anti-fibrotic properties. However, its role and molecu...

Autotaxin Inhibition Ameliorates HFpEF Phenotype By Reducing LPA-Mediated Systemic Inflammation and Cardiac Remodeling

In male mice with established two-hit HFpEF, autotaxin inhibition improved diastolic indices and reduced fibrosis, hypertrophy and cardiac myeloid accumulation and the autotaxin–LPA axis is nominated as a tractable therapeutic target.

Hongqi Shenmai Decoction ameliorates post-myocardial infarction heart failure by preserving mitochondrial cardiolipin homeostasis via attenuation of EGFR/JAK2-STAT3 signaling.

BACKGROUND Post-myocardial infarction heart failure (post-MI HF) is driven by adverse ventricular remodeling and mitochondrial dysfunction. Cardiolipin is essential for mitochondrial integrity, but its upstream regulation in failing myocardium remains unclear. Whether Hongqi Shenmai Decoction (HQSMD) preserves cardioli...

Exploring the cardioprotective role of metformin against isoproterenol-induced myocardial infarction using computational, cellular, and animal models

Targeting PKGIα Cys42 attenuates cardiac dysfunction in heart failure with preserved ejection fraction

In a multihit HFpEF model, urolithin A improved diastolic function and attenuated cardiac remodeling through cysteine 42–dependent activation of PKGIα, and was validated in human engineered heart tissue, where urolithin A enhanced both relaxation and contraction kinetics.

FGFR1/KLB-MFG-E8 Maintains Microvascular Integrity and Adaptive Cardiac Remodeling

BACKGROUND: Endothelial defects in the heart are a contributor to cardiac pathological remodeling and dysfunction, which can be influenced by cardiomyocytes. Here, we explore cardioprotective crosstalk between cardiomyocytes and endothelial cells under diabetic conditions. METHODS: Type 2 diabetes was induced in male a...