This comprehensive review synthesizes recent advances in lactate biology, encompassing the expanding enzymatic landscape of lactylation—including newly identified writers, erasers, and readers—and their roles in neurodegenerative diseases and critically re-examine metabolic coupling models beyond the classical astrocyte-neuron lactate shuttle.
Historically, research has viewed substantial brain metabolic activity through the lens of energy production, primarily treating metabolites as substrates and products in bioenergetic pathways. However, this paradigm is now evolving. Key metabolic intermediates are recognized not only as components of Adenosine Triphos...
Song Wang, Si-Chen Wang, Yu-Han Sun et al.· Current Neuropharmacology· 0 citations
Alzheimer’s disease (AD) is characterized by cerebral glucose hypome-tabolism, an early hallmark through neuroimaging and neuropathological investigations. Previous researches have established the phenomenon of reduced glucose uptake. Building upon this established knowledge, the field is now increasingly focused on el...
Min-Min Chen, Chang-Min Zuo, Run-Zhi Li et al.· Discover Neuroscience· 0 citations
This review critically examines the molecular and spatial architecture of glucose metabolism in the parkinsonian brain and evaluates the therapeutic potential of emerging metabolic modulators, including terazosin, cordycepin, and GLP-1 receptor agonists.
Ying Yi, Cen Chen, You He et al.· Medicinal research reviews (...· 0 citations
A deeper understanding of lactate flux and lactylation-dependent vulnerabilities may enable biomarker-guided combinations that integrate metabolic intervention, epigenetic modulation, and immuno-oncology for precision cancer therapy.
Jia-Yi Chen, An-Qi He, Si-Yi Zhu et al.· Journal of Pathology· 0 citations
Cancer cells undergo profound metabolic reprogramming to sustain uncontrolled proliferation within a nutrient-limited and often hypoxic tumor microenvironment (TME). Metabolic rewiring is an active driver of oncogenesis, immune evasion, epigenetic remodeling, and therapy resistance. Over the past century, our understan...
Niti Kumari, Surendra K. Shukla, Ravi Thakur· Pharmacology and Therapeutic...· 0 citations
This review summarizes the metabolic mechanisms underlying lactate production and lactylation within the inflammatory microenvironment, and discusses how the lactate-lactylation axis relates to the dynamic “alteration-exudation-proliferation” trajectory of inflammation.
Xin Huang, Ya-Qiao Zhu, Ruiming Guo et al.· Oral Science and Homeostatic...· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
