TL;DR
Three techniques are described, surface plasmon resonance, protein microarray, and flow cytometry, to distinguish affinities of monoclonal antibodies specific to the Hen Egg Lysozyme, Ovalbumin, and Duffy (HOD) fusion model antigen.
Antigen-specific antibodies that bind to antigens play vital roles in adaptive immune defense; specifically, these are: Targeting and destroying bacteria, viruses, and other pathogens; forming immunological memory against previously encountered pathogens for future protection; diagnostic testing; and the development of...
This work will examine the development and use of B cell tetramers for the purpose of studying antigen-specific B cell responses following RBC transfusion.
The structural and functional properties of human IgG and IgA subclasses are reviewed with a focus on anti-CD20 rituximab in two- and three-dimensional models of human B-cell lymphoma, to highlight opportunities to refine antibody isotype selection for more individualized cancer immunotherapy.
The protocols in this chapter outline the design, production, and evaluation of HLA-Fc proteins, emphasizing their efficacy in vitro and in immunodeficient mouse models, potentially providing new therapeutic approaches for managing HLA-sensitized patients in clinical practice.
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